Montmorillonite‐lecithin‐heparin/PDMS films with enhanced mechanical and antithrombogenic properties

Abstract This study developed a polymer/layered silicate film as blood‐contacting devices. First, the lecithin‐heparin (LEC‐HEP) was used to modify pristine montmorillonite (MMT). LEC‐HEP was successfully exchanged in the MMT. The organically modified MMT was used for the synthesis of poly(dimethylsiloxane) (PDMS)/MMT‐LEC‐HEP films by intercalation solution technique. The morphological, structural of the prepared film were evaluated using X‐ray diffraction, scanning electron microscopy. LEC‐HEP‐MMT concentration of 0.5 wt% in PDMS systems enhanced mechanical properties. The hemocompatibility of PDMS/LEC‐HEP‐MMT films was evaluated by hemolysis assay, dynamic coagulation time, and plasma recalcification time (PRT). PDMS/0.5 wt% LEC‐HEP‐MMT films also exhibited higher blood anticoagulant indexes, longer the PRT and lower hemolysis rate than the corresponding PDMS film.