Systemically Administered Hemostatic Nanoparticles for Identification and Treatment of Internal Bleeding

Manos Gkikas; Thomas Peponis; Tomaz Mesar; Celestine Hong; Reginald K. Avery; Emmanuel Roussakis; Hyung-Jin Yoo; Anushri Parakh; Manuel Patino; Dushyant V. Sahani; Michael T. Watkins; Rahmi Oklu; Conor L. Evans; Hassan Albadawi; George Velmahos; Bradley D. Olsen

doi:10.1021/acsbiomaterials.9b00054

journal article·2019-05-13Open access

Systemically Administered Hemostatic Nanoparticles for Identification and Treatment of Internal Bleeding

Manos Gkikas, Thomas Peponis, Tomaz Mesar, Celestine Hong, Reginald K. Avery, Emmanuel Roussakis, Hyung-Jin Yoo, Anushri Parakh, Manuel Patino, Dushyant V. Sahani, Michael T. Watkins, Rahmi Oklu, Conor L. Evans, Hassan Albadawi, George Velmahos, Bradley D. Olsen

ACS Biomaterials Science & Engineering· Volume 5· Issue 5

Publisher page Open full text

Source abstract

Abstract

Internal bleeding is an injury that can be difficult to localize and effectively treat without invasive surgeries. Injectable polymeric nanoparticles have been developed that can reduce clotting times and blood loss, but they have yet to incorporate sufficient diagnostic capabilities to assist in identifying bleeding sources. Herein, polymeric nanoparticles were developed to simultaneously treat internal bleeding while incorporating tracers for visualization of the nanoparticles by standard clinical imaging modalities. Addition of 1,1'-dioctadecyl-3,3,3',3'-tetramethylindodicarbocyanine perchlorate (DiD; a fluorescent dye), biotin functionality, and gold nanoparticles to hemostatic polymeric nanoparticles resulted in nanoparticles amenable to imaging with near-infrared (NIR) imaging, immunohistochemistry, and X-ray computed tomography (CT), respectively. Following a lethal liver resection injury, visualization of accumulated nanoparticles by multiple imaging methods was achieved in rodents, with the highest accumulation observed at the liver injury site, resulting in improved survival rates. Tracer addition to therapeutic nanoparticles allows for an expansion of their applicability, during stabilization by first responders to diagnosis and identification of unknown internal bleeding sites by clinicians using standard clinical imaging modalities.

Source: openalex_inverted_index · Quality: baseline

Research context

Polymers Nanomaterials

OpenAlex topics: Hemostasis and retained surgical items · Trauma, Hemostasis, Coagulopathy, Resuscitation · Blood transfusion and management

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Department of Chemistry, University of Massachusetts Lowell, Lowell, Massachusetts 01854, United States

Department of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02144, United States

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Wellman Center for Photomedicine, Massachusetts General Hospital, Charlestown, Massachusetts 02129, United States

Division of Vascular and Endovascular Surgery, Massachusetts General Hospital, Boston, Massachusetts 02144, United States

Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts 02144, United States

Division of Vascular and Interventional Radiology, Mayo Clinic, Scottsdale, Arizona 85259, United States

Funding

Army Research Office · National Institutes of Health

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