Progress of Photodynamic and RNAi Combination Therapy in Cancer Treatment
Source abstract
Abstract
Photodynamic therapy (PDT) is a noninvasive and effective local treatment for cancers that produces selective damage to target tissues and cells. However, PDT alone is unlikely to completely inhibit tumor metastasis and/or local tumor recurrence. RNA interference (RNAi) is a phenomenon of gene silencing mediated by exogenous or endogenous double-stranded RNA (dsRNA). RNAi has entered a golden period of development, with the approval of four treatments employing RNAi. PDT in combination with RNAi therapy to inhibit related targets has been a research hotspot, with better clinical outcomes than monotherapy. In this review, the progress of PDT and small interfering RNA (siRNA) targeting different genes is discussed, while the achievements of the combined immunotherapy are reviewed.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · RNA Interference and Gene Delivery · Photodynamic Therapy Research Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Life Science; Advanced Research Institute of Multidisciplinary Science; Institute of Engineering Medicine; Key Laboratory of Molecular Medicine and Biotherapy, Beijing Institute of Technology, Beijing 100081, China
Funding
Ministry of Science and Technology of the People's Republic of China · Natural Science Foundation of??Hunan Province · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Beijing Nova Program · Huxiang Youth Talent Support Program · Young Elite Scientist Sponsorship Program of Beijing Association for Science and Technology · Beijing-Tianjin-Hebei Basic Research Cooperation Project
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