DataVXACS Biomaterials Science & EngineeringPaper
journal article·2017-12-11

Near-Infrared Guided Thermal-Responsive Nanomedicine against Orthotopic Superficial Bladder Cancer

Hui Gao, Ying Bi, Xin Wang, Miao Wang, Mengxue Zhou, Huiru Lu, Jimin Gao, Jun Chen, Yi Hu

ACS Biomaterials Science & Engineering· Volume 3· Issue 12
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Source abstract

Abstract

Nanomedicines have shown great promise in increasing the efficacy and preventing adverse effects of drugs for bladder cancer. Here we sought to examine the effect of chemo-photothermal therapy on an orthotopic mouse model of superficial bladder cancer. Doxorubicin (DOX) was encapsulated in CS/PNIPAAm@SWCNTs nanoparticles. The biodistribution and antitumor effects of DOX-loaded nanoparticles were analyzed. DOX-loaded nanoparticles were accumulated in tumor cells upon near-infrared (NIR) irradiation and exhibited strong antitumor activity in mice bearing orthotopic bladder tumors. In addition, NIR-induced hyperthermia enhanced the permeability of tumor blood vessels, which presumably accounted for specific targeting of the nanomedicines to tumors. These results suggest that NIR-guided thermal-responsive nanomedicines are potentially applicable for chemo-photothermal therapy against orthotopic bladder tumors.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Bladder and Urothelial Cancer Treatments · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Laboratory Medicine and Life Science, Wenzhou Medical University, University Town, Wenzhou, Zhejiang 325035, China

Clinical Laboratory Department, Children’s Hospital of Zhejiang University School of Medicine, No. 3333 Binsheng Road, Changhe Subdistrict, Binjiang District, Hangzhou, Zhejiang 310052, China

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), 19B Yuquan Road, Beijing 100049, China

University of Chinese Academy of Sciences, 19B Yuquan Road, Beijing 100049, China

Funding

Ministry of Science and Technology of the People's Republic of China · Ministry of Health of the People's Republic of China · Youth Innovation Promotion Association of the Chinese Academy of Sciences · National Natural Science Foundation of China · Chinese Academy of Sciences · Natural Science Foundation of Zhejiang Province · Zhejiang Province

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