Preparation and blood compatibility of electrospun nanofibrous CTS/PLA mats from chitosan nanopowders and poly(lactic acid)
Source abstract
Abstract
Chitosan nanopowder (NCTS) was prepared through ball milling. NCTS was successfully electrospun to nanofibers with the assistance of poly(lactic acid) (PLA) to prepare electrospun mats (NCTS/PLA). Scanning electron microscope images revealed that there were no chitosan particles in NCTS/PLA, indicating NCTS had been stretched to nanofibers. The effects of the electrospinning parameters (voltage, distance, and NCTS amount) on the morphology of NCTS/PLA were investigated. X‐ray photoelectron spectroscopy verified the existence of chitosan in the mats. All the NCTS/PLA mats had a water contact angle higher than 130°, showing good hydrophobicity. NCTS/PLA expressed good blood compatibility according to the results of coagulation time and platelet adhesion experiment. NCTS/PLA had a little longer activated partial thrombin time than PLA and more NCTS leaded longer coagulation times. No platelets aggregation and deformation appeared on NCTS/PLA mats. POLYM. COMPOS., 39:E416–E425, 2018. © 2017 Society of Plastics Engineers
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · biodegradable polymer synthesis and properties · Polymer Nanocomposite Synthesis and Irradiation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Hainan Provincial Fine Chemical Engineering Research Center Hainan University Haikou Hainan 570228 People's Republic of China
Affiliated Haikou Hospital, Xiangya School of Medicine central south University, Haikou Municipal People's Hospital Haikou Hainan 570208 People's Republic of China
Funding
National Natural Science Foundation of China
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