Assembling Human Platelet Lysate into Multiscale 3D Scaffolds for Bone Tissue Engineering
Source abstract
Abstract
Scaffolds for bone tissue engineering lack often control of cellular instructions. We propose a triple sequential approach for customizing scaffold features from the macro to the nanoscale. The nano/mesoscale is composed by human platelet lysate and marine-origin polysaccharides assembled by layer-by-layer and shaped into fibrils by freeze-drying. We show that osteogenic induction of stem cells is tunable within a low range of layers. This approach has the potential to develop new scaffolds with enhanced cell-instructive capabilities using affordable autologous sources of bioactive molecules.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Periodontal Regeneration and Treatments · Bone Tissue Engineering Materials · 3D Printing in Biomedical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
3B’s Research Group−Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, AvePark Taipas, Guimarães 4806-909, Portugal
ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães 4806-909, Portugal
Funding
European Research Council · European Commission · Funda??o para a Ci?ncia e a Tecnologia
References (41)
Show source-provided references
1. 10.1002/adma.20080297710.1002/adma.200802977 ↗
2. 10.1016/S0142-9612(00)00120-410.1016/S0142-9612(00)00120-4 ↗
3. 10.1016/j.jconrel.2012.06.00110.1016/j.jconrel.2012.06.001 ↗
4. 10.1016/j.addr.2010.01.00110.1016/j.addr.2010.01.001 ↗
5. 10.1016/S1079-2104(98)90029-410.1016/S1079-2104(98)90029-4 ↗
6. 10.1054/jcms.2002.028510.1054/jcms.2002.0285 ↗
7. 10.3928/01477447-20130523-1010.3928/01477447-20130523-10 ↗
8. 10.1302/0301-620X.90B7.2023510.1302/0301-620X.90B7.20235 ↗
9. 10.1016/j.biomaterials.2012.08.05410.1016/j.biomaterials.2012.08.054 ↗
10. 10.1186/1471-2474-14-33010.1186/1471-2474-14-330 ↗
11. 10.1016/j.biomaterials.2005.10.03910.1016/j.biomaterials.2005.10.039 ↗
12. 10.1111/j.1600-0501.2006.01327.x10.1111/j.1600-0501.2006.01327.x ↗
13. 10.1038/sj.bjp.070672210.1038/sj.bjp.0706722 ↗
14. 10.1016/j.dental.2012.08.00110.1016/j.dental.2012.08.001 ↗
15. 10.1002/adma.20110447510.1002/adma.201104475 ↗
16. 10.1016/j.biomaterials.2011.04.03610.1016/j.biomaterials.2011.04.036 ↗
17. 10.1002/smll.20080080410.1002/smll.200800804 ↗
18. 10.1021/bm301080810.1021/bm3010808 ↗
19. 10.1007/BF0043747010.1007/BF00437470 ↗
20. 10.1006/abbi.1993.100510.1006/abbi.1993.1005 ↗
21. Folkman, J.; Shing, Y.InHeparin and Related Polysaccharides;Springer:New York, 1992; pp355–364.10.1007/978-1-4899-2444-5_34 ↗
22. 10.1038/nature0581710.1038/nature05817 ↗
23. 10.1039/c3cs60393h10.1039/c3cs60393h ↗
24. 10.1021/cm402126n10.1021/cm402126n ↗
25. 10.1021/cm203245910.1021/cm2032459 ↗
26. 10.1021/cr400531v10.1021/cr400531v ↗
27. 10.1002/adhm.20120020410.1002/adhm.201200204 ↗
28. 10.5037/jomr.2011.210210.5037/jomr.2011.2102 ↗
29. 10.1016/j.biomaterials.2009.09.04310.1016/j.biomaterials.2009.09.043 ↗
30. 10.1016/j.actbio.2013.02.00310.1016/j.actbio.2013.02.003 ↗
31. 10.1039/c3tb20624f10.1039/c3tb20624f ↗
32. 10.1002/smll.20100106610.1002/smll.201001066 ↗
33. 10.1371/journal.pone.005545110.1371/journal.pone.0055451 ↗
34. 10.1016/S0092-8674(00)80257-310.1016/S0092-8674(00)80257-3 ↗
35. 10.1096/fj.05-4221fje10.1096/fj.05-4221fje ↗
36. 10.1359/jbmr.07080410.1359/jbmr.070804 ↗
37. 10.3109/03008207.2011.61160110.3109/03008207.2011.611601 ↗
38. 10.1002/jcp.2239210.1002/jcp.22392 ↗
39. 10.1007/s12015-010-9147-010.1007/s12015-010-9147-0 ↗
40. 10.1074/jbc.M21161020010.1074/jbc.M211610200 ↗
41. 10.1016/S0014-5793(00)01372-710.1016/S0014-5793(00)01372-7 ↗