DataVXACS Biomaterials Science & EngineeringPaper
journal article·2018-08-13

Core–Shell Structurized Fe3O4@C@MnO2 Nanoparticles as pH Responsive T1-T2* Dual-Modal Contrast Agents for Tumor Diagnosis

Beichen Duan, Dongdong Wang, Huihui Wu, Pengping Xu, Peng Jiang, Guoliang Xia, Zhenbang Liu, Haibao Wang, Zhen Guo, Qianwang Chen

ACS Biomaterials Science & Engineering· Volume 4· Issue 8
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Source abstract

Abstract

Biocompatible core–shell Fe3O4@C@MnO2 nanoparticles (named as FOCMO NPs) with an average size at 130 nm prepared through an effortless yet efficient strategy were employed as pH-activatable T1-T2* dual-modality magnetic resonance imaging (MRI) contrast agents (CAs). The release rate of Mn ions in acidic PBS (pH = 5.0) was approximately 10 times to that under condition with pH value of 7.4. Benefiting from excellent acid responsiveness, which facilitates the release of ions from FOCMO NPs at tumor region with acidic microenvironment and organelles, the diagnosis accuracy was commendably improved. After intravenous injection of FOCMO NPs, an efficiently intensive contrast in tumors are realized with a distinct enhancement of 127% in T1 MRI signal 24 h after the administration. Moreover, a significant decreasement of 71% is witnessed in T2 MRI signal. Those demonstrated that FOCMO NPs can achieve the purpose of positive/negative MRI simultaneously. Furthermore, obtained FOCMO NPs showed great hemocompatibility and negligible toxicity.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Lanthanide and Transition Metal Complexes · Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Hefei National Laboratory for Physical Sciences at Microscale, Department of Materials Science and Engineering, University of Science and Technology of China, No.96, JinZhai Road, Hefei 230026, People’s Republic of China

Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, School of Life Sciences, University of Science and Technology of China, No.96, JinZhai Road, Hefei 230027, People’s Republic of China

Radiology Department of the First Affiliated Hospital of Anhui Medical University, No.218, Jixi Road, Hefei, 230022, People’s Republic of China

High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, No.350 Shushanhu Road, Hefei 230031, People’s Republic of China

Funding

Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China

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