journal article·2021-11-08

Antibacterial Hydrogel with Self-Healing Property for Wound-Healing Applications

Yunyi Bo, Linhua Zhang, Zhifeng Wang, Jiafu Shen, Ziwei Zhou, Yan Yang, Yong Wang, Jianglei Qin, Yingna He

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Abstract

-[3-(dimethylamino)propyl] methacrylamide (quaternized P(DMAPMA-DMA-DAA)) bearing copolymers with dithiodipropionic acid dihydrazide (DTDPH) as cross-linker. The hydrogels presented efficient self-healing capability as well as a pH and redox-triggered gel-sol-gel transition property that is based on the dynamic acylhydrazone bond and disulfide linkage. Furthermore, the hydrogels showed good antibacterial activity, biocompatibility, degradability, and sustained release ability. More importantly, the in vivo experiments demonstrated that the hydrogels loaded with mouse epidermal growth factor (mEGF) significantly accelerated wound closure by preventing bacterial infection and promoting cutaneous regeneration in the wound model. The antibacterial hydrogels with self-healing behavior hold great potential in wound treatment.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Wound Healing and Treatments · Hydrogels: synthesis, properties, applications · 3D Printing in Biomedical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Pharmaceutical College, Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, China

Key Laboratory of Biomedical Material of Tianjin, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China

College of Chemistry and Environmental Science, Hebei University, Baoding, Hebei 071002, China

Key Laboratory of Pathogenesis mechanism and control of inflammatory-autoimmune diseases in Hebei Province, Hebei University, Baoding, Hebei 071002, China

Hebei Higher Education Institute Applied Technology Research Center on TCM Formula Preparation, Shijiazhuang, Hebei 050200, China

Funding

Natural Science Foundation of Hebei Province · National Natural Science Foundation of China · Scientific research program of Hebei Administration of TCM · State key laboratory of organic-Inorganic composites · Science and Technology Project of Hebei Education Department

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