journal article·2022-01-10Open access

Zn–Mg–WC Nanocomposites for Bioresorbable Cardiovascular Stents: Microstructure, Mechanical Properties, Fatigue, Shelf Life, and Corrosion

Zeyi Guan, Chase S. Linsley, Shuaihang Pan, Gongcheng Yao, Benjamin M. Wu, Daniel S. Levi, Xiaochun Li

Abstract

Zinc (Zn) and Zn alloys have been studied as potential materials for bioresorbable stents (BRSs) in the last decade due to their favorable biodegradability and biocompatibility. However, most Zn alloys lack the necessary combination of strength, ductility, fatigue resistance, corrosion rate (CR), and thermal stability needed for such applications. In this study, nanoparticles made of tungsten carbide (WC) were successfully incorporated into Zn alloyed with 0.5 wt % magnesium (Mg) and evaluated for their suitability for BRS applications. Specifically, the resulting Zn–0.5Mg–WC nanocomposite’s microstructure, mechanical properties, in vitro CR, and thermal stability were evaluated. The Zn–0.5Mg–WC nanocomposite had excellent mechanical strength [ultimate tensile strength (UTS) > 250 MPa], elongation to failure (>30%), and a suitable in vitro CR (∼0.02 mm/y) for this clinical application. Moreover, the Zn–0.5Mg–WC nanocomposite survived 10 million cycles of tensile loading (stress ratio, R = 0.053) when the maximum stress was 80% of the yield stress. Its ductility was also retained during a 90-day thermal stability study, indicating an excellent shelf life. Stent prototypes were fabricated using this composition and were successfully deployed during bench testing without fracture. These results show that the Zn–0.5Mg–WC nanocomposite is a promising material for BRS applications. In vivo studies are underway to validate both biocompatibility, stent function, and degradation.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Magnesium Alloys: Properties and Applications · Advanced materials and composites · Orthopaedic implants and arthroplasty

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Mechanical & Aerospace Engineering, Samueli School of Engineering, University of California, Los Angeles, 420 Westwood Plaza, 48-121 Engineering IV, Los Angeles, California 90095, United States

Department of Bioengineering, Samueli School of Engineering, University of California, Los Angeles, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, California 90095, United States

Department of Materials Science & Engineering, Samueli School of Engineering, University of California, Los Angeles. 410 Westwood Plaza, 3111 Engineering V, Los Angeles, California 90095, United States

Division of Advanced Prosthodontics, School of Dentistry, University of California, Los Angeles, 10833 Le Conte Avenue, CHS B3-087, Los Angeles, California 90095, United States

Department of Orthopedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90095, United States

Department of Pediatrics, Division of Cardiology, Children’s Heart Center 330, UCLA Mattel Children’s Hospital, Los Angeles. 200 Medical Plaza, Los Angeles, California 90095, United States

Department of Medicine, Ahmanson Adult Congenital Heart Disease Center, David Geffen School of Medicine at UCLA, 100 Medical Plaza Driveway Suite 630, Los Angeles, California 90095, United States

Funding

National Heart, Lung, and Blood Institute

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