DataVXACS Biomaterials Science & EngineeringPaper
journal article·2018-09-10

Copper-Modified Ti6Al4 V Suppresses Inflammatory Response and Osteoclastogenesis while Enhancing Extracellular Matrix Formation for Osteoporotic Bone Regeneration

Xiongcheng Xu, Yanjin Lu, Xue Yang, Zhibin Du, Ling Zhou, Shuman Li, Chao Chen, Kai Luo, Jinxin Lin

ACS Biomaterials Science & Engineering· Volume 4· Issue 9
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Source abstract

Abstract

Copper has been reported to promote bone regeneration by increasing osteogenesis and decreasing inflammation and osteoclastogenesis. However, information on the effects of copper on osteoporotic cells involved in bone regeneration is scarce in the literature. In the current study, Ti6Al4 V-6 wt %Cu (Ti6Al4 V-Cu) was fabricated by selective laser melting (SLM) technology, and the effects of copper on the behaviors of osteoporotic and nonosteoporotic macrophages, osteoclasts, and osteoblasts were evaluated by comparison with Ti6Al4 V. Our results showed that Ti6Al4 V-Cu inhibited the activation, viability, and pro-inflammatory cytokine secretion of osteoporotic macrophages and decreased osteoclast formation and down-regulated osteoclast differentiation-related genes and proteins of osteoporotic osteoclasts. Furthermore, the bone extracellular matrix formation of osteoporotic osteoblasts was up-regulated by Ti6Al4 V-Cu. In conclusion, SLM-fabricated Ti6Al4 V-Cu exhibited excellent anti-inflammation and antiosteoclast capability, optimized extracellular matrix formation, and holds great potential for bone regeneration in osteoporotic patients.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Bone Tissue Engineering Materials · Titanium Alloys Microstructure and Properties · Orthopaedic implants and arthroplasty

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Fujian Biological Materials Engineering and Technology Center of Stomatology, School and Hospital of Stomatology, Fujian Medical University, 246 Yangqiao Zhong Road, Fuzhou 350002, China

Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 West Yangqiao Road, Fuzhou 350002, China

University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 1000049, China

Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove Campus, Brisbane, 4059 Queensland, Australia

Department of Stomatology, Fujian Provincial Geriatric Hospital, 147 Beihuan Zhong Road, Fuzhou 350002, China

Funding

Ministry of Science and Technology of the People's Republic of China · Natural Science Foundation of Fujian Province · Chinese Academy of Sciences · Fujian Provincial Development and Reform Commission · Fujian Province

References (55)

Show source-provided references
1. 10.1016/j.it.2013.09.00110.1016/j.it.2013.09.001 ↗
2. 10.4317/medoral.1829810.4317/medoral.18298 ↗
3. 10.1111/j.1600-0757.1998.tb00132.x10.1111/j.1600-0757.1998.tb00132.x ↗
4. 10.1016/j.jpor.2012.12.00110.1016/j.jpor.2012.12.001 ↗
5. 10.3290/j.qi.a3713310.3290/j.qi.a37133 ↗
6. 10.1021/acsbiomaterials.6b0012110.1021/acsbiomaterials.6b00121 ↗
7. 10.1016/j.msec.2015.01.02310.1016/j.msec.2015.01.023 ↗
8. 10.1002/jor.2307510.1002/jor.23075 ↗
9. 10.1128/AEM.02766-1010.1128/AEM.02766-10 ↗
10. 10.1016/j.jmst.2013.12.01410.1016/j.jmst.2013.12.014 ↗
11. 10.1038/srep2998510.1038/srep29985 ↗
12. 10.1179/1753555714Y.000000023710.1179/1753555714Y.0000000237 ↗
13. 10.3390/ma1010115410.3390/ma10101154 ↗
14. 10.1007/s10856-012-4839-410.1007/s10856-012-4839-4 ↗
15. 10.2217/nnm.16.3910.2217/nnm.16.39 ↗
16. 10.1016/j.biomaterials.2010.01.00210.1016/j.biomaterials.2010.01.002 ↗
17. 10.1002/jbm.b.3331810.1002/jbm.b.33318 ↗
18. 10.1016/j.biomaterials.2012.09.06610.1016/j.biomaterials.2012.09.066 ↗
19. 10.1177/088532821771335610.1177/0885328217713356 ↗
20. 10.1007/s00198-013-2410-x10.1007/s00198-013-2410-x ↗
21. 10.1016/j.msec.2018.04.04610.1016/j.msec.2018.04.046 ↗
22. 10.1016/j.msec.2016.11.12610.1016/j.msec.2016.11.126 ↗
23. 2012
24. 10.1007/s00441-015-2167-y10.1007/s00441-015-2167-y ↗
25. 10.1002/jbm.b.3086110.1002/jbm.b.30861 ↗
26. 10.3892/etm.2015.263210.3892/etm.2015.2632 ↗
27. 10.1038/bonekey.2014.8010.1038/bonekey.2014.80 ↗
28. 10.4415/ANN_15_03_1110.4415/ANN_15_03_11 ↗
29. 10.7860/JCDR/2014/9957.527210.7860/JCDR/2014/9957.5272 ↗
30. 10.1038/bonekey.2013.10710.1038/bonekey.2013.107 ↗
31. 10.1021/acsbiomaterials.6b0000610.1021/acsbiomaterials.6b00006 ↗
32. 10.1021/acsbiomaterials.7b0067910.1021/acsbiomaterials.7b00679 ↗
33. 10.1172/JCI4449010.1172/JCI44490 ↗
34. 10.1186/1742-4933-2-1410.1186/1742-4933-2-14 ↗
35. 10.1155/2014/31613410.1155/2014/316134 ↗
36. 10.1186/s13287-016-0276-510.1186/s13287-016-0276-5 ↗
37. 10.1007/s10856-013-5041-z10.1007/s10856-013-5041-z ↗
38. 10.1074/mcp.M113.03074210.1074/mcp.M113.030742 ↗
39. 10.1108/eb05867010.1108/eb058670 ↗
40. 10.1016/j.mam.2005.07.01310.1016/j.mam.2005.07.013 ↗
41. 10.4012/dmj.2010-08810.4012/dmj.2010-088 ↗
42. 10.1016/j.cell.2007.07.02510.1016/j.cell.2007.07.025 ↗
43. 10.1038/nrrheum.2015.4810.1038/nrrheum.2015.48 ↗
44. 10.3945/an.110.00027310.3945/an.110.000273 ↗
45. 10.1038/sj.emboj.760148910.1038/sj.emboj.7601489 ↗
46. 10.1111/j.1753-4887.1987.tb06081.x10.1111/j.1753-4887.1987.tb06081.x ↗
47. 10.1007/s00198-009-1066-z10.1007/s00198-009-1066-z ↗
48. 10.1016/S8756-3282(96)00283-910.1016/S8756-3282(96)00283-9 ↗
49. 10.1021/acsami.7b0652110.1021/acsami.7b06521 ↗
50. 10.1371/journal.pone.018210910.1371/journal.pone.0182109 ↗
51. 10.2147/IJN.S14686610.2147/IJN.S146866 ↗
52. 10.1016/j.biomaterials.2015.02.11210.1016/j.biomaterials.2015.02.112 ↗
53. 10.1016/S0887-2333(99)00058-210.1016/S0887-2333(99)00058-2 ↗
54. 10.1016/j.actbio.2012.12.00310.1016/j.actbio.2012.12.003 ↗
55. 10.1016/j.colsurfb.2013.06.00710.1016/j.colsurfb.2013.06.007 ↗