journal article·2019-05-13

Manganese-Based Magnetic Layered Double Hydroxide Nanoparticle: A pH-Sensitive and Concurrently Enhanced T1/T2-Weighted Dual-Mode Magnetic Resonance Imaging Contrast Agent

Wensheng Xie, Zhenhu Guo, Zhenbang Cao, Qin Gao, Dan Wang, Cyrille Boyer, Maria Kavallaris, Xiaodan Sun, Xiumei Wang, Lingyun Zhao, Zi Gu

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Abstract

The interference effect and lack of selectivity are the bottlenecks for dual-mode magnetic resonance imaging (MRI) contrast agent development. To address these challenges and overcome the single mode imaging contrast limitations, a novel MgMnAl-layered double hydroxide@iron oxide nanoparticle (MgMnAl-LDH@IO NP) has been successfully synthesized as a concurrently enhanced dual-mode contrast agent for MRI of tumor tissues with sensitive pH response and high efficacy. The attachment of iron oxide nanoparticles on the surface of MgMnAl-LDH NPs led to the increased local magnetic field intensity, inducing the concurrent enhancement of both T1 and T2 relaxivity. The in vitro MRI demonstrated that the MgMnAl-LDH@IO NP could act as a pH-sensitive contrast agent for both T1- and T2-weighted MR imaging (r1, 5.67 mM-1 s-1 under pH 5.0 and 1.98 mM-1 s-1 under pH 7.4; r2, 369.12 mM-1 s-1 under pH 5.0 and 225.29 mM-1 s-1 under pH 7.4). The biocompatibility of the dual-mode contrast agent was revealed by the cytotoxicity test on fibroblast cells. Further in vivo dual-mode MR imaging exhibited that the MgMnAl-LDH@IO NP showed clear T1- and T2-weighted MR imaging of tumor tissues in breast-tumor-bearing mice. The facile synthetic method, desirable biocompatibility, sensitive stimuli response, and concurrently enhanced T1/T2 MRI signals both in vitro and in vivo encourage the great potential biomedical and clinical applications of MgMnAl-LDH@IO NP in MR imaging with improved accuracy.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Lanthanide and Transition Metal Complexes · Luminescence Properties of Advanced Materials · Magnetism in coordination complexes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science & Engineering, Tsinghua University, 35 Qinghua East Street, Haidian District, Beijing 100084, China

Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science & Engineering, Tsinghua University, 35 Qinghua East Street, Haidian District, Beijing 100084, China

School of Chemical Engineering, University of New South Wales, High Street, Sydney, New South Wales 2052, Australia

Australian Centre for Nanomedicine (ACN), University of New South Wales, Sydney, New South Wales 2052, Australia

Sinopec Beijing Yanshan Petrochemical Co., Ltd., No. 1 Yanshangang South Road, Fangshan District, Beijing 102500, China

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney, New South Wales 2052, Australia

Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales 2052, Australia

Funding

National Natural Science Foundation of China · Tsinghua University · University of New South Wales · National Health and Medical Research Council · Australian Centre for NanoMedicine, University of New South Wales

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