In Situ 3D Label-Free Contactless Bioprinting of Cells through Diamagnetophoresis
Source abstract
Abstract
Using whole blood, we demonstrate the first realization of a novel macroscale, contactless, label-free method to print in situ three-dimensional (3D) cell assemblies of different morphologies and sizes. This novel bioprinting method does not use nozzles that can contaminate the cell suspension, or to which cells can adhere. Instead, we utilize the intrinsic diamagnetic properties of whole blood cells to magnetically manipulate them in situ in a nontoxic paramagnetic medium, creating (a) rectangular bar, (b) three-pointed star, and (c) spheroids of varying sizes. We envision the technique to be transferable to other cell lines, with potential applications in tissue engineering and drug screening.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Microfluidic and Bio-sensing Technologies · 3D Printing in Biomedical Research · Microfluidic and Capillary Electrophoresis Applications
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Affiliations
Department of Mechanical Engineering, §School of Biomedical Engineering, ⊥McMaster Immunology Research Center, and ∥Department of Engineering Physics, McMaster University, 1280 Main Street West, Hamilton, OntarioL8S 4L7, Canada
Funding
Canada Foundation for Innovation · Natural Sciences and Engineering Research Council of Canada · McMaster University · Fraunhofer-Institut für Zelltherapie und Immunologie
References (28)
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