Metabolizable Small Gold Nanorods: Size-dependent Cytotoxicity, Cell Uptake and In Vivo Biodistribution
Source abstract
Abstract
Gold nanorods (AuNRs) with unique plasmonic properties in the near-infrared region have promising biomedical applications but suffer from poor in vivo clearance because of the large size. In this study, small AuNRs with a diameter of 7 nm (designated as sAuNRs) are found to have low toxicity and high clearance rates in vivo . Compared to common AuNRs with a diameter of 14 nm (designated as bAuNRs), sAuNRs exhibit similar surface plasmon resonance bands and photothermal efficiency as bAuNRs but have lower cytotoxicity as well as higher cell uptake. The in vivo biodistribution study indicates that only 0.68% of the intravenously injected sAuNRs remain in the body after 30 days, but the residual amount in the body after injection of bAuNRs is as high as 12.3%. The results demonstrate that the smaller AuNRs having lower toxicity and increased clearance in vivo have large clinical potential.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong P. R. China
School and Hospital of Stomatology, Wuhan University, Wuhan 430079, Hubei P. R. China
Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong
Funding
Research Grants Council, University Grants Committee, Hong Kong · China Postdoctoral Science Foundation · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Science and Technology Key Projects of Shenzhen
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