DataVXACS Biomaterials Science & EngineeringPaper
journal article·2021-08-09Open access

Biodegradable, Tissue Adhesive Polyester Blends for Safe, Complete Wound Healing

John L. Daristotle, Metecan Erdi, Lung W. Lau, Shadden T. Zaki, Priya Srinivasan, Manogna Balabhadrapatruni, Omar B. Ayyub, Anthony D. Sandler, Peter Kofinas

ACS Biomaterials Science & Engineering· Volume 7· Issue 8
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Source abstract

Abstract

Pressure-sensitive adhesives typically used for bandages are nonbiodegradable, inhibiting healing, and may cause an allergic reaction. Here, we investigated the effect of biodegradable copolymers with promising thermomechanical properties on wound healing for their eventual use as biodegradable, biocompatible adhesives. Blends of low molecular weight (LMW) and high molecular weight (HMW) poly(lactide-co-caprolactone) (PLCL) are investigated as tissue adhesives in comparison to a clinical control. Wounds treated with PLCL blend adhesives heal completely with similar vascularization, scarring, and inflammation indicators, yet require fewer dressing changes due to integration of the PLCL adhesive into the wound. A blend of LMW and HMW PLCL produces an adhesive material with significantly higher adhesive strength than either neat polymer. Wound adhesion is comparable to a polyurethane bandage, utilizing conventional nonbiodegradable adhesives designed for extremely strong adhesion.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersBiomaterials

OpenAlex topics: Surgical Sutures and Adhesives · Wound Healing and Treatments · biodegradable polymer synthesis and properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Fischell Department of Bioengineering, University of Maryland, 3102 A. James Clark Hall, 8278 Paint Branch Dr., College Park, Maryland 20742, United States

Department of Chemical and Biomolecular Engineering, University of Maryland, 4418 Stadium Dr., College Park, Maryland 20742, United States

Sheikh Zayed Institute for Pediatric Surgical Innovation, Joseph E. Robert Jr. Center for Surgical Care, Children’s National Medical Center, 111 Michigan Avenue NW, Washington, District of Columbia 20010, United States

Department of Materials Science and Engineering, University of Maryland, 4418 Stadium Dr., College Park, Maryland 20742, United States

Funding

National Institute of Biomedical Imaging and Bioengineering · University of Maryland

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