Antibacterial methacrylamide chitosan-modified viscose/poly(ε-caprolactone) hydrogel membranes for wound healing
Source abstract
Abstract
Abstract Herein, antibacterial ChMA and tannic acid modified viscose/poly(ε-caprolactone) (PCL) fibrous hydrogel membranes were developed for accelerating wound healing. The morphology, chemical structure, swelling capacity, degradation, mechanical, antibacterial properties and cell viability of the modified membranes were investigated. The results indicated that the ChMA/tannic acid modified viscose membranes exhibited a larger swelling ratio ca. 200% and a lower degradability than the modified PCL membrane. The tensile strength and elongation at break of the ChMA/tannic acid modified PCL membrane were about 3.2 ± 0.4 MPa and 618.2 ± 18.2%, respectively, larger than the values of the modified viscose membrane. Simultaneously, both of the ChMA/TA modified viscose and PCL hydrogel membranes showed high-efficiency antibacterial ratio against S. aureus (95%) and a DPPH free radical scavenging rate (91%). Moreover, the modified viscose membranes maintained superior cytocompatibility and accelerated the wound healing process in vivo. The as-prepared modified hydrogel membranes enabled the maintenance of high bioavailability of tannic acid and synchronization with the porous structure of ChMA hydrogels, which enhanced the wound healing performance of the fibrous membrane. Considering the ease of accessibility of viscose and the simplicity of the current approach, the ChMA/tannic acid modified viscose hydrogel membranes have great potential in wound dressings.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Wound Healing and Treatments · Electrospun Nanofibers in Biomedical Applications · Hydrogels: synthesis, properties, applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (44)
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