journal article·2022-12-12

Engineered Biomimetic Membranes for Organ-on-a-Chip

Maedeh Rahimnejad, Fariba Rasouli, Sepideh Jahangiri, Sepideh Ahmadi, Navid Rabiee, Marzieh Ramezani Farani, Omid Akhavan, Mohsen Asadnia, Yousef Fatahi, Sanghoon Hong, Jungho Lee, Junmin Lee, Sei Kwang Hahn

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Abstract

Organ-on-a-chip (OOC) systems are engineered nanobiosystems to mimic the physiochemical environment of a specific organ in the body. Among various components of OOC systems, biomimetic membranes have been regarded as one of the most important key components to develop controllable biomimetic bioanalysis systems. Here, we review the preparation and characterization of biomimetic membranes in comparison with the features of the extracellular matrix. After that, we review and discuss the latest applications of engineered biomimetic membranes to fabricate various organs on a chip, such as liver, kidney, intestine, lung, skin, heart, vasculature and blood vessels, brain, and multiorgans with perspectives for further biomedical applications.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: 3D Printing in Biomedical Research · Innovative Microfluidic and Catalytic Techniques Innovation · Neuroscience and Neural Engineering

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Biomedical Engineering Institute, School of Medicine, Université de Montréal, Montreal, Quebec H3T 1J4, Canada

Research Centre, Centre Hospitalier de l’Université de Montréal (CRCHUM), Montreal, Quebec H2X 0A9, Canada

Bioceramics and Implants Laboratory, Faculty of New Sciences and Technologies, University of Tehran, Tehran 14174-66191, Iran

Department of Biomedical Sciences, Faculty of Medicine, Université de Montréal, Montreal, Quebec H3T 1J4, Canada

Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran 19839-63113, Iran

Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran 19839-63113, Iran

Department of Physics, Sharif University of Technology, Tehran 11155-9161, Iran

School of Engineering, Macquarie University, Sydney, New South Wales 2109, Australia

Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Korea

Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), the Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran 14176-14411, Iran

Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14176-14411, Iran

Funding

National Research Foundation of Korea

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