journal article·2020-11-09

Theranostic Prospects of Graphene Quantum Dots in Breast Cancer

Rahul S. Tade, Pravin O. Patil

Publisher page

Abstract

Breast cancer (BC) is increasing as a significant cause of mortality among women. In this context, early diagnosis and treatment strategies for BC are being developed by researchers at the cellular level using advanced nanomaterials. However, immaculate etiquette is the prerequisite for their implementation in clinical practice. Considering the stolid nature of cancer, combining diagnosis and therapy (theranostics) using graphene quantum dots (GQDs) is a prime focus and challenge for researchers. In a nutshell, GQDs is a new shining star among various fluorescent materials, which has acclaimed fame in a short duration in materials science and the biomedical field as well. From this perspective, we review various strategies in BC treatment using GQDs alone or in combination. In addition, the photophysical properties of GQDs explored in photothermal therapy, hyperthermia therapy, and photodynamic therapy are also discussed. Moreover, we also focus on the strategic use of GQDs both as drug carriers and as combinatorial-guided drug delivery motifs. This Review provides an update for the scientific community to plan and expand advanced theranostic horizons in BC using GQDs.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Carbon and Quantum Dots Applications · Graphene and Nanomaterials Applications · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur-425405, Maharashtra, India

Funding

Science and Engineering Research Board

References (96)

Show source-provided references
1. 10.1001/jamaoncol.2019.146010.1001/jamaoncol.2019.1460 ↗
2. 10.1016/j.suc.2020.01.00210.1016/j.suc.2020.01.002 ↗
3. 10.1200/JCO.2015.62.286010.1200/JCO.2015.62.2860 ↗
4. World Health Organization, WHO report on cancer: setting priorities, investing wisely and providing care for all, 2020; https://apps.who.int/iris/handle/10665/330745.
5. 10.1007/s11095-008-9661-910.1007/s11095-008-9661-9 ↗
6. World Health Organization · 2019
7. 10.3322/caac.2149210.3322/caac.21492 ↗
8. 10.1007/s10549-006-9397-310.1007/s10549-006-9397-3 ↗
9. 10.7497/j.issn.2095-3941.2015.003010.7497/j.issn.2095-3941.2015.0030 ↗
10. 10.7150/jca.1845710.7150/jca.18457 ↗
11. 10.3233/BD-2010-030710.3233/BD-2010-0307 ↗
12. 10.1016/S0140-6736(11)61539-010.1016/S0140-6736(11)61539-0 ↗
13. 10.1007/s10549-010-0894-z10.1007/s10549-010-0894-z ↗
14. Singh D. · 202010.2217/nnm-2019-0401 ↗
15. 10.1038/nm.449410.1038/nm.4494 ↗
16. 10.1148/rg.24103505210.1148/rg.241035052 ↗
17. Alkabban F. M. · 2019
18. 10.1093/annonc/mdz28910.1093/annonc/mdz289 ↗
19. 10.1186/bcr57710.1186/bcr577 ↗
20. 10.21873/anticanres.1341010.21873/anticanres.13410 ↗
21. 10.1016/j.tips.2015.08.00910.1016/j.tips.2015.08.009 ↗
22. 10.1136/jitc-2019-00017310.1136/jitc-2019-000173 ↗
23. 10.1093/jnci/51.5.140910.1093/jnci/51.5.1409 ↗
24. Comşa Ş. · Anticancer Res. · 2015 · 35 · 3147
25. 10.1155/2019/217971810.1155/2019/2179718 ↗
26. 10.1007/s12274-008-8021-810.1007/s12274-008-8021-8 ↗
27. 10.1021/nn501640q10.1021/nn501640q ↗
28. 10.1126/science.115466310.1126/science.1154663 ↗
29. 10.1002/biot.20190042210.1002/biot.201900422 ↗
30. 10.1021/acsbiomaterials.6b0039010.1021/acsbiomaterials.6b00390 ↗
31. 10.1088/1361-6528/ab803e10.1088/1361-6528/ab803e ↗
32. 10.1039/C4NR02494J10.1039/C4NR02494J ↗
33. 10.1016/j.ejmech.2019.11162010.1016/j.ejmech.2019.111620 ↗
34. Feng, S.; Li, H.; Pan, J.; Li, C.; Zheng, Y. Preparation and cell imaging of nitrogen-doped graphene quantum dot conjugated indomethacin. IOP Conference Series: Earth and Environmental Science; IOP Publishing, 2019; 032006.10.1088/1755-1315/358/3/032006 ↗
35. 10.1016/j.apmt.2018.11.01110.1016/j.apmt.2018.11.011 ↗
36. 10.1002/anie.20150062610.1002/anie.201500626 ↗
37. 10.1002/smll.20170371010.1002/smll.201703710 ↗
38. 10.1002/adma.20090282510.1002/adma.200902825 ↗
39. 10.1039/C7TB01073G10.1039/C7TB01073G ↗
40. 10.1039/C8CS00543E10.1039/C8CS00543E ↗
41. 10.1186/1556-276X-9-10810.1186/1556-276X-9-108 ↗
42. 10.1038/s41551-020-0540-y10.1038/s41551-020-0540-y ↗
43. 10.1021/acs.jpclett.9b0389110.1021/acs.jpclett.9b03891 ↗
44. 10.1038/s41598-019-48567-610.1038/s41598-019-48567-6 ↗
45. 10.2217/nnm-2018-001810.2217/nnm-2018-0018 ↗
46. 10.1021/acs.nanolett.8b0324910.1021/acs.nanolett.8b03249 ↗
47. 10.1016/j.jfluchem.2018.04.00310.1016/j.jfluchem.2018.04.003 ↗
48. 10.5772/6193210.5772/61932 ↗
49. 10.1039/C8TB00153G10.1039/C8TB00153G ↗
50. 10.3892/mco.2014.35610.3892/mco.2014.356 ↗
51. 10.1021/acsami.6b0236110.1021/acsami.6b02361 ↗
52. 10.1038/nrc107110.1038/nrc1071 ↗
53. 10.1021/acsnano.8b0189310.1021/acsnano.8b01893 ↗
54. 10.1021/acs.langmuir.6b0418910.1021/acs.langmuir.6b04189 ↗
55. 10.1002/smll.20160222510.1002/smll.201602225 ↗
56. 10.1021/acsomega.6b0038510.1021/acsomega.6b00385 ↗
57. 10.1021/acsami.6b1670510.1021/acsami.6b16705 ↗
58. 10.1021/acsami.7b0726710.1021/acsami.7b07267 ↗
59. 10.1016/j.biomaterials.2017.10.03410.1016/j.biomaterials.2017.10.034 ↗
60. 10.1016/j.pdpdt.2018.10.02110.1016/j.pdpdt.2018.10.021 ↗
61. 10.1016/j.ica.2019.01.01210.1016/j.ica.2019.01.012 ↗
62. 10.1016/j.dyepig.2019.03.00210.1016/j.dyepig.2019.03.002 ↗
63. 10.1007/s10853-019-04062-x10.1007/s10853-019-04062-x ↗
64. 10.22038/IJMP.2018.1288610.22038/IJMP.2018.12886 ↗
65. 10.1002/adtp.20190018310.1002/adtp.201900183 ↗
66. 10.1039/C6RA25976F10.1039/C6RA25976F ↗
67. 10.1016/j.biomaterials.2019.11970010.1016/j.biomaterials.2019.119700 ↗
68. 10.1021/acsomega.7b0153910.1021/acsomega.7b01539 ↗
69. 10.1016/j.jssc.2019.12110710.1016/j.jssc.2019.121107 ↗
70. 10.1002/jbio.20180036710.1002/jbio.201800367 ↗
71. 10.1021/acs.bioconjchem.7b0046610.1021/acs.bioconjchem.7b00466 ↗
72. 10.1002/adfm.20180586010.1002/adfm.201805860 ↗
73. 10.2147/IJN.S18855210.2147/IJN.S188552 ↗
74. 10.1021/nl400368v10.1021/nl400368v ↗
75. 10.1088/1361-6528/ab5f7f10.1088/1361-6528/ab5f7f ↗
76. 10.1088/1361-6528/ab2cb410.1088/1361-6528/ab2cb4 ↗
77. 10.1021/acsami.9b2138510.1021/acsami.9b21385 ↗
78. 10.1038/srep0285210.1038/srep02852 ↗
79. 10.1016/j.nano.2016.03.01010.1016/j.nano.2016.03.010 ↗
80. 10.1142/9789813202559_000710.1142/9789813202559_0007 ↗
81. 10.1016/j.msec.2016.05.00710.1016/j.msec.2016.05.007 ↗
82. 10.1021/acsami.7b0882410.1021/acsami.7b08824 ↗
83. 10.1097/COC.000000000000056310.1097/COC.0000000000000563 ↗
84. 10.1039/C6RA25949A10.1039/C6RA25949A ↗
85. 10.1016/j.msec.2017.05.04910.1016/j.msec.2017.05.049 ↗
86. 10.3892/ijo.2013.206310.3892/ijo.2013.2063 ↗
87. 10.1002/adhm.20130006610.1002/adhm.201300066 ↗
88. 10.1016/j.msec.2018.09.02010.1016/j.msec.2018.09.020 ↗
89. 10.1016/S1470-2045(07)70074-810.1016/S1470-2045(07)70074-8 ↗
90. 10.1002/emmm.20110013610.1002/emmm.201100136 ↗
91. 10.1007/s11051-019-4700-510.1007/s11051-019-4700-5 ↗
92. 10.1083/jcb.20180416110.1083/jcb.201804161 ↗
93. 10.3390/nano1001009110.3390/nano10010091 ↗
94. 10.1016/j.carbpol.2009.11.04710.1016/j.carbpol.2009.11.047 ↗
95. 10.1016/j.biomaterials.2010.01.08910.1016/j.biomaterials.2010.01.089 ↗
96. 10.1016/j.msec.2020.11088810.1016/j.msec.2020.110888 ↗