DataVXACS Biomaterials Science & EngineeringPaper
journal article·2021-03-08

A Biomimetic Zinc Alloy Scaffold Coated with Brushite for Enhanced Cranial Bone Regeneration

Yu Zhuang, Qingcheng Liu, Gaozhi Jia, Hongliang Li, Guangyin Yuan, Hongbo Yu

ACS Biomaterials Science & Engineering· Volume 7· Issue 3
Publisher page
Source abstract

Abstract

Bone tissue engineering is considered as a promising pathway for bone regeneration and defect reconstruction, in which scaffolds play an important role. Zn alloy, which is a biodegradable metal material that has advantages of metallic and biodegradable characteristics, has its special features, especially the ideal degradation rate and acceptable biocompatibility, which make it worthy to be further investigated for medical applications. In this study, new biodegradable porous Zn alloy scaffolds with Ca–P coating were attempted to repair cranial bone defect, and in vitro and in vivo assays were conducted to evaluate its biocompatibility, osteo-inductivity, and osteo-conductivity. The results indicated that coated Zn alloy possessed good biocompatibility, with no cytotoxicity. It could also promote osteogenic differentiation and calcium deposition of rabbit BMSCs in vitro, and new bone formation around the scaffold in vivo . The biodegradable porous Zn alloy scaffold with Ca–P coating is considered to be promising in cranial bone defect repair.
Source: openalex_inverted_index · Quality: baseline

Research context

Metals & alloysBiomaterialsMaterials processing

OpenAlex topics: Cell Image Analysis Techniques · CCD and CMOS Imaging Sensors · Image Processing Techniques and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology; National Clinical Research Center for Oral Diseases, Shanghai 200011, China

National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composite, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China

Funding

Shanghai Jiao Tong University · Shanghai Jiao Tong University School of Medicine · National Natural Science Foundation of China · Clinical Research Program of 9th People's Hospital · Three Year Action Plan to Promote Clinical Skills and Clinical Creativity in Municipal Hospitals

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