Graphene Foam as a Three-Dimensional Platform for Myotube Growth

Eric Krueger; A. Nicole Chang; Dale Brown; Josh Eixenberger; Raquel Brown; Sepideh Rastegar; Katie M. Yocham; Kurtis D. Cantley; David Estrada

doi:10.1021/acsbiomaterials.6b00139

journal article·2016-08-08Open access

Graphene Foam as a Three-Dimensional Platform for Myotube Growth

Eric Krueger, A. Nicole Chang, Dale Brown, Josh Eixenberger, Raquel Brown, Sepideh Rastegar, Katie M. Yocham, Kurtis D. Cantley, David Estrada

ACS Biomaterials Science & Engineering· Volume 2· Issue 8

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Source abstract

Abstract

This study demonstrates the growth and differentiation of C2C12 myoblasts into functional myotubes on three-dimensional graphene foam bioscaffolds. Specifically, we establish both bare and laminin-coated graphene foam as a biocompatible platform for muscle cells and identify that electrical coupling stimulates cell activity. Cell differentiation and functionality is determined by the expression of myotube heavy chain protein and Ca 2+ fluorescence, respectively. Further, our data show that the application of a pulsed electrical stimulus to the graphene foam initiates myotube contraction and subsequent localized substrate movement of over 100 μm. These findings will further the development of advanced three-dimensional graphene platforms for therapeutic applications and tissue engineering.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials Biomaterials

OpenAlex topics: Graphene and Nanomaterials Applications · Bone Tissue Engineering Materials · Graphene research and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Micron School of Materials Science and Engineering, §Biomolecular Research Center, ⊥Physics Department and Biomolecular Sciences Doctoral Program, ∥Department of Electrical and Computer Engineering, and #Department of Mechanical and Biomedical Engineering, Boise State University, 1910 University Drive, Boise, Idaho 83725, United States

Funding

Division of Chemistry · Division of Biological Infrastructure · MJ Murdock Charitable Trust · National Institute of General Medical Sciences · Idaho State Board of Education · Micron School of Materials Science, Boise State University

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