Biocompatible Magnetic Conjugated Polymer Nanoparticles for Optical and Lifetime Imaging Applications in the First Biological Window
Source abstract
Abstract
Conjugated polymers are organic semiconductors that can be used for fluorescence microscopy of living specimens. Here, we report the encapsulation of the bright-red-emitting conjugated polymer, poly[{9,9-dihexyl-2,7-bis(1-cyanovinylene)fluorenylene}-alt-co-{2,5-bis(N,N'-diphenylamino)-1,4-phenylene}] (CN-FO-DPD), and superparamagnetic iron oxide nanoparticles (SPIONs) within poly(styrene-co-maleic anhydride) (PSMA) micelles. The resulting particles exhibited an emission peak at 657 nm, a fluorescence quantum yield of 21%, an average diameter of 65 nm, and a ζ potential of -30 mV. They are taken up by cells, and we describe their use in fluorescence microscopy of living Hela cells and zebrafish embryos and their associated cytotoxicity in HEK, HeLa, and HCE cells.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Luminescence and Fluorescent Materials · Conducting polymers and applications · Supramolecular Self-Assembly in Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Physics, King′s College London, London WC2R 2LS, U.K.
Randall Centre for Cell and Molecular Biophysics, Faculty of Life Sciences and Medicine, King’s College London, London SE1 1UL, U.K.
Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, U.K.
Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Universitätsring 1, 1010 Vienna, Austria
Funding
Wellcome Trust · FP7 Ideas: European Research Council
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