Aptasensors Based on Graphene Field-Effect Transistors for Arsenite Detection
Source abstract
Abstract
All-electronic chemical sensors based on field-effect transistors (FETs) hold tremendous promise for rapid and sensitive detection of arsenic in groundwater. Their sensitivity, however, is fundamentally limited by a chemical gating mechanism where target ion charges are directly measured. We have developed a highly sensitive aptasensor, based on scalable graphene FETs, which relies on the conformational change of the negatively charged aptamer upon arsenite binding, offering a wide analytical range, from 0.05 to 1000 ppb, and with a 0.02 ppb detection limit. Circular dichroism spectroscopy studies confirmed the conformational change of the aptamer, and molecular dynamic studies further validated that arsenite had bound with the hairpin loop of the aptamer. This work provides a highly accurate chemical sensing platform for rapid detection of arsenic in drinking water.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Graphene research and applications · Molecular Junctions and Nanostructures
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, NT, Hong Kong 999077, P. R. China
Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, P. R. China
Shenzhen Research Institute, The Chinese University of Hong Kong, No.10, 2nd, Yuexing Road, Nanshan, Shenzhen 518057, P. R. China
Funding
Research Grants Council, University Grants Committee · Hong Kong Government · National Natural Science Foundation of China · Key Area Research and Development Program of Guangdong Province
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