Shape changing thin films powered by DNA hybridization
Source abstract
Abstract
Active materials that respond to physical and chemical stimuli can be used to build dynamic micromachines that lie at the interface between biological systems and engineered devices. In principle, the specific hybridization of DNA can be used to form a library of independent, chemically driven actuators for use in such microrobotic applications and could lead to device capabilities that are not possible with polymer- or metal-layer-based approaches. Here, we report shape changing films that are powered by DNA strand exchange reactions with two different domains that can respond to distinct chemical signals. The films are formed from DNA-grafted gold nanoparticles using a layer-by-layer deposition process. Films consisting of an active and a passive layer show rapid, reversible curling in response to stimulus DNA strands added to solution. Films consisting of two independently addressable active layers display a complex suite of repeatable transformations, involving eight mechanochemical states and incorporating self-righting behaviour.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Micro and Nano Robotics · Modular Robots and Swarm Intelligence
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (31)
Show source-provided references
1. Na, J.-H. et al. Programming reversibly self-folding origami with micropatterned photo-crosslinkable polymer trilayers. Adv. Mater. 27, 79–85 (2015).10.1002/adma.201403510 ↗
2. Wang, E., Desai, M. S. & Lee, S.-W. Light-controlled graphene–elastin composite hydrogel actuators. Nano Lett. 13, 2826–2830 (2013).10.1021/nl401088b ↗
3. Feinberg, A. W. et al. Muscular thin films for building actuators and powering devices. Science 317, 1366–1370 (2007).10.1126/science.1146885 ↗
4. Shim, T. S., Kim, S.-H., Heo, C.-J., Jeon, H. C. & Yang, S.-M. Controlled origami folding of hydrogel bilayers with sustained reversibility for robust microcarriers. Angew. Chem. Int. Ed. 51, 1420–1423 (2012).10.1002/anie.201106723 ↗
5. Bassik, N. et al. Enzymatically triggered actuation of miniaturized tools. J. Am. Chem. Soc. 132, 16314–16317 (2010).10.1021/ja106218s ↗
6. Palleau, E., Morales, D., Dickey, M. D. & Velev, O. D. Reversible patterning and actuation of hydrogels by electrically assisted ionoprinting. Nature Commun. 4, 2257 (2013).10.1038/ncomms3257 ↗
7. Kim, S., Laschi, C. & Trimmer, B. Soft robotics: a bioinspired evolution in robotics. Trends Biotechnol. 31, 287–294 (2013).10.1016/j.tibtech.2013.03.002 ↗
8. Nawroth, J. C. et al. A tissue-engineered jellyfish with biomimetic propulsion. Nat. Biotechnol. 30, 792–797 (2012).10.1038/nbt.2269 ↗
9. Estephan, Z. G., Qian, Z., Lee, D., Crocker, J. C. & Park, S. J. Responsive multidomain free-standing films of gold nanoparticles assembled by DNA-directed layer-by-layer approach. Nano Lett. 13, 4449–4455 (2013).10.1021/nl4023308 ↗
10. Mirkin, C. A., Letsinger, R. L., Mucic, R. C. & Storhoff, J. J. A DNA-based method for rationally assembling nanoparticles into macroscopic materials. Nature 382, 607–609 (1996).10.1038/382607a0 ↗
11. Alivisatos, A. P. et al. Organization of ‘nanocrystal molecules’ using DNA. Nature 382, 609–611 (1996).10.1038/382609a0 ↗
12. Storhoff, J. J., Elghanian, R., Mucic, R. C., Mirkin, C. A. & Letsinger, R. L. One-pot colorimetric differentiation of polynucleotides with single base imperfections using gold nanoparticle probes. J. Am. Chem. Soc. 120, 1959–1964 (1998).10.1021/ja972332i ↗
13. Noh, H. et al. 50 nm DNA nanoarrays generated from uniform oligonucleotide films. ACS Nano 3, 2376–2382 (2009).10.1021/nn900559m ↗
14. Kannan, B., Kulkarni, R. P. & Majumdar, A. DNA-based programmed assembly of gold nanoparticles on lithographic patterns with extraordinary specificity. Nano Lett. 4, 1521–1524 (2004).10.1021/nl049247a ↗
15. Tison, C. K. & Milam, V. T. Reversing DNA-mediated adhesion at a fixed temperature. Langmuir 23, 9728–9736 (2007).10.1021/la700601j ↗
16. Tison, C. K. & Milam, V. T. Programming the kinetics and extent of colloidal disassembly using a DNA trigger. Soft Matter 6, 4446–4453 (2010).10.1039/c0sm00222d ↗
17. Baker, B. A., Mahmoudabadi, G. & Milam, V. T. Strand displacement in DNA-based materials systems. Soft Matter 9, 11160–11172 (2013).10.1039/c3sm52157e ↗
18. McGinley, J. T., Jenkins, I., Sinno, T. & Crocker, J. C. Assembling colloidal clusters using crystalline templates and reprogrammable DNA interactions. Soft Matter 9, 9119–9128 (2013).10.1039/c3sm50950h ↗
19. Rogers, W. B. & Manoharan, V. N. Programming colloidal phase transitions with DNA strand displacement. Science 347, 639–642 (2015).10.1126/science.1259762 ↗
20. Maye, M. M., Kumara, M. T., Nykypanchuk, D., Sherman, W. B. & Gang, O. Switching binary states of nanoparticle superlattices and dimer clusters by DNA strands. Nature 5, 116–120 (2010).
21. Zhang, Y. et al. Selective transformations between nanoparticle superlattices via the reprogramming of DNA-mediated interactions. Nat. Mater. 14, 840–847 (2015).10.1038/nmat4296 ↗
22. Kim, Y., Macfarlane, R. J., Jones, M. R. & Mirkin, C. A. Transmutable nanoparticles with reconfigurable surface ligands. Science 351, 579–582 (2016).10.1126/science.aad2212 ↗
23. Sebba, D. S., Mock, J. J., Smith, D. R., Labean, T. H. & Lazarides, A. A. Reconfigurable core–satellite nanoassemblies as molecularly-driven plasmonic switches. Nano Lett. 8, 1803–1808 (2008).10.1021/nl080029h ↗
24. Yurke, B., Turberfield, A. J., Mills, A. P. Jr, Simmel, F. C. & Neumann, J. L. A DNA-fuelled molecular machine made of DNA. Nature 406, 605–608 (2000).10.1038/35020524 ↗
25. Liu, L., Jiang, S., Sun, Y. & Agarwal, S. Giving direction to motion and surface with ultra-fast speed using oriented hydrogel fibers. Adv. Funct. Mater. 26, 1021–1027 (2015).10.1002/adfm.201503612 ↗
26. Chen, X. J. et al. Self-assembled hybrid structures of DNA block-copolymers and nanoparticles with enhanced DNA binding properties. Small 6, 2256–2260 (2010).10.1002/smll.201001185 ↗
27. Mitchell, G. P., Mirkin, C. A. & Letsinger, R. L. Programmed assembly of DNA functionalized quantum dots. J. Am. Chem. Soc. 121, 8122–8123 (1999).10.1021/ja991662v ↗
28. Murakami, Y. & Maeda, M. DNA-responsive hydrogels that can shrink or swell. Biomacromolecules 6, 2927–2929 (2005).10.1021/bm0504330 ↗
29. Turkevich, J., Stevenson, P. C. & Hillier, J. The formation of colloidal gold. J. Phys. Chem. 57, 670–673 (1953).10.1021/j150508a015 ↗
30. Frens, G. Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions. Nature 241, 20–22 (1973).
31. Liu, X., Atwater, M., Wang, J. & Huo, Q. Extinction coefficient of gold nanoparticles with different sizes and different capping ligands. Colloids Surf. B 58, 3–7 (2007).10.1016/j.colsurfb.2006.08.005 ↗