Nanoscale NMR spectroscopy and imaging of multiple nuclear species
Source abstract
Abstract
Nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) provide non-invasive information about multiple nuclear species in bulk matter, with wide-ranging applications from basic physics and chemistry to biomedical imaging. However, the spatial resolution of conventional NMR and MRI is limited to several micrometres even at large magnetic fields (>1 T), which is inadequate for many frontier scientific applications such as single-molecule NMR spectroscopy and in vivo MRI of individual biological cells. A promising approach for nanoscale NMR and MRI exploits optical measurements of nitrogen-vacancy (NV) colour centres in diamond, which provide a combination of magnetic field sensitivity and nanoscale spatial resolution unmatched by any existing technology, while operating under ambient conditions in a robust, solid-state system. Recently, single, shallow NV centres were used to demonstrate NMR of nanoscale ensembles of proton spins, consisting of a statistical polarization equivalent to ∼100-1,000 spins in uniform samples covering the surface of a bulk diamond chip. Here, we realize nanoscale NMR spectroscopy and MRI of multiple nuclear species ((1)H, (19)F, (31)P) in non-uniform (spatially structured) samples under ambient conditions and at moderate magnetic fields (∼20 mT) using two complementary sensor modalities.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Diamond and Carbon-based Materials Research · Atomic and Subatomic Physics Research · High-pressure geophysics and materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (37)
Show source-provided references
1. Mansfield, P. Snapshot magnetic resonance imaging (Nobel lecture). Angew. Chem. Int. Ed. 43, 5456–5464 (2004).10.1002/anie.200460078 ↗
2. Glover, P. & Mansfield, P. Limits to magnetic resonance microscopy. Rep. Progr. Phys. 65, 1489 (2002).10.1088/0034-4885/65/10/203 ↗
3. Taylor, J. M. et al. High-sensitivity diamond magnetometer with nanoscale resolution. Nature Phys. 4, 810–816 (2008).10.1038/nphys1075 ↗
4. Maze, J. R. et al. Nanoscale magnetic sensing with an individual electronic spin in diamond. Nature 455, 644–647 (2008).10.1038/nature07279 ↗
5. Balasubramanian, G. et al. Nanoscale imaging magnetometry with diamond spins under ambient conditions. Nature 455, 648–651 (2008).10.1038/nature07278 ↗
6. Mamin, H. J. et al. Nanoscale nuclear magnetic resonance with a nitrogen vacancy center. Science 339, 557–560 (2013).10.1126/science.1231540 ↗
7. Staudacher, T. et al. Nuclear magnetic resonance spectroscopy on a (5-nanometer)3 sample volume. Science 339, 561–563 (2013).10.1126/science.1231675 ↗
8. Bending, S. J. Local magnetic probes of superconductors. Adv. Phys. 48, 449–535 (1999).10.1080/000187399243437 ↗
9. Budker, D. & Romalis, M. Optical magnetometry. Nature Phys. 3, 227–234 (2007).10.1038/nphys566 ↗
10. Nowack, K. C. et al. Imaging currents in HgTe quantum wells in the quantum spin Hall regime. Nature Mater. 12, 787–791 (2013).10.1038/nmat3682 ↗
11. Rugar, D., Budakian, R., Mamin, H. J. & Chui, B. W. Single spin detection by magnetic resonance force microscopy. Nature 430, 329–332 (2004).10.1038/nature02658 ↗
12. Degen, C., Poggio, M., Mamin, H., Rettner, C. & Rugar, D. Nanoscale magnetic resonance imaging. Proc. Natl Acad. Sci. USA 106, 1313–1317 (2009).10.1073/pnas.0812068106 ↗
13. Childress, L. et al. Coherent dynamics of coupled electron and nuclear spin qubits in diamond. Science 314, 281–285 (2006).10.1126/science.1131871 ↗
14. Bar-Gill, N. et al. Suppression of spin-bath dynamics for improved coherence of multi-spin-qubit systems. Nature Commun. 3, 858 (2012).10.1038/ncomms1856 ↗
15. Belthangady, C. et al. Dressed-state resonant coupling between bright and dark spins in diamond. Phys. Rev. Lett. 110, 157601 (2013).10.1103/PhysRevLett.110.157601 ↗
16. Kolkowitz, S., Unterreithmeier, Q. P., Bennett, S. D. & Lukin, M. D. Sensing distant nuclear spins with a single electron spin. Phys. Rev. Lett. 109, 137601 (2012).10.1103/PhysRevLett.109.137601 ↗
17. Taminiau, T. et al. Detection and control of individual nuclear spins using a weakly coupled electron spin. Phys. Rev. Lett. 109, 137602 (2012).10.1103/PhysRevLett.109.137602 ↗
18. Grinolds, M. S. et al. Sub-nanometer resolution in three-dimensional magnetic resonance imaging of individual dark spins. Nature Nanotech. 9, 279–284 (2014).10.1038/nnano.2014.30 ↗
19. Grinolds, M. S. et al. Nanoscale magnetic imaging of a single electron spin under ambient conditions. Nature Phys. 9, 215–219 (2013).10.1038/nphys2543 ↗
20. Loretz, M., Pezzagna, S., Meijer, J. & Degen, C. L. Nanoscale nuclear magnetic resonance with a 1.9-nm-deep nitrogen-vacancy sensor. Appl. Phys. Lett. 104, 033102 (2014).10.1063/1.4862749 ↗
21. Sushkov, A. O. et al. All-optical sensing of a single-molecule electron spin. Nano Lett. 14, 6443–6448 (2014).10.1021/nl502988n ↗
22. Le Sage, D. et al. Optical magnetic imaging of living cells. Nature 496, 486–489 (2013).10.1038/nature12072 ↗
23. Sushkov, A. O. et al. Magnetic resonance detection of individual proton spins using quantum reporters. Phys. Rev. Lett. 113, 197601 (2014).10.1103/PhysRevLett.113.197601 ↗
24. Pham, L. M. et al. Magnetic field imaging with nitrogen-vacancy ensembles. New J. Phys. 13, 045021 (2011).10.1088/1367-2630/13/4/045021 ↗
25. Gullion, T., Baker, D. B. & Conradi, M. S. New, compensated Carr–Purcell sequences. J. Magn. Reson. 89, 479–484 (1990).
26. de Lange, G., Ristè, D., Dobrovitski, V. V. & Hanson, R. Single-spin magnetometry with multi-pulse dynamical decoupling sequences. Phys. Rev. Lett. 106, 080802 (2011).10.1103/PhysRevLett.106.080802 ↗
27. Naydenov, B. et al. Dynamical decoupling of a single-electron spin at room temperature. Phys. Rev. B 83, 081201 (2011).10.1103/PhysRevB.83.081201 ↗
28. Ryan, C. A., Hodges, J. S. & Cory, D. G. Robust decoupling techniques to extend quantum coherence in diamond. Phys. Rev. Lett. 105, 200402 (2010).10.1103/PhysRevLett.105.200402 ↗
29. Bar-Gill, N., Pham, L. M., Jarmola, A., Budker, D. & Walsworth, R. Solid-state electronic spin coherence time approaching one second. Nature Commun. 4, 1743 (2013).10.1038/ncomms2771 ↗
30. Cywiński, Ł., Lutchyn, R. M., Nave, C. P. & Das Sarma, S. How to enhance dephasing time in superconducting qubits. Phys. Rev. B 77, 174509 (2008).10.1103/PhysRevB.77.174509 ↗
31. Bylander, J. et al. Noise spectroscopy through dynamical decoupling with a superconducting flux qubit. Nature Phys. 7, 565–570 (2011).10.1038/nphys1994 ↗
32. Hall, L. T., Cole, J. H., Hill, C. D. & Hollenberg, L. C. L. Sensing of fluctuating nanoscale magnetic fields using nitrogen-vacancy centers in diamond. Phys. Rev. Lett. 103, 220802 (2009).10.1103/PhysRevLett.103.220802 ↗
33. Fuller, G. H. Nuclear Spins and Moments (American Chemical Society, 1976).10.1063/1.555544 ↗
34. Mamin, H. et al. Isotope-selective detection and imaging of organic nanolayers. Nano Lett. 9, 3020–3024 (2009).10.1021/nl901466p ↗
35. Xue, F., Weber, D. P., Peddibhotla, P. & Poggio, M. Measurement of statistical nuclear spin polarization in a nanoscale GaAs sample. Phys. Rev. B 84, 205328 (2011).10.1103/PhysRevB.84.205328 ↗
36. Arai, K. et al. Fourier magnetic imaging with nanoscale resolution and compressed sensing speed-up using electronic spins in diamond. Preprint at http://arxiv.org/abs/1409.2749 (2014).
37. Kessler, E. M., Lovchinsky, I., Sushkov, A. O. & Lukin, M. D. Quantum error correction for metrology. Phys. Rev. Lett. 112, 150802 (2014).10.1103/PhysRevLett.112.150802 ↗