journal article·2006-12-01

Programmable self-assembly of metal ions inside artificial DNA duplexes

Kentaro Tanaka, Guido H. Clever, Yusuke Takezawa, Yasuyuki Yamada, Corinna Kaul, Mitsuhiko Shionoya, Thomas Carell

Nature Nanotechnology· Volume 1· Issue 3
Publisher page

Abstract

The ultimate bottom-up approach for the construction of functional nanosystems requires the precise arrangement of atoms and molecules in three dimensions. DNA is currently one of the most prominent molecules able to self-assemble into complex networks and is therefore regarded as the 'silicon of the nano-world'. Metals and metal ions, in contrast, are the atomic building-blocks needed in such materials to establish functions such as electrical conductivity or magnetism. Here we report a new concept, which efficiently combines metal ions and DNA. The DNA structure is used as a matrix to program robustly the complexation of different metal ions under precise control with regard to element, number and composition.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · DNA and Nucleic Acid Chemistry · Nanopore and Nanochannel Transport Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (17)

Show source-provided references
1. Gothelf, K. V. & LaBean, T. H. DNA-programmed assembly of nanostructures. Org. Biomol. Chem. 3, 4023–4037 (2005).10.1039/b510551j ↗
2. Tanaka, K. & Shionoya, M. Bio-inspired programmable self-assembly on DNA templates. Chem. Lett. 35, 694–699 (2006).10.1246/cl.2006.694 ↗
3. Luo, D & Li Y. Nucleic acid engineered nanomaterials and their applications. Handbook of Nanostructured Biomaterials and their Applications in Nanobiotechnology 2, 223–345 (American Scientific Publishers, Stevenson Ranch, 2005).
4. Marquis, A. et al. Messages in molecules: ligand/cation coding and self-recognition in a constitutionally dynamic system of heterometallic double helicates. Chem. Eur. J. 12, 5632–5641 (2006).10.1002/chem.200600143 ↗
5. Gait, K. J. (ed.) Oligonucleotide Synthesis: A Practical Approach (IRL Press, New York, 1990).
6. Tanaka, K. et al. A discrete self-assembled metal array in artificial DNA. Science 299, 1212–1213 (2003).10.1126/science.1080587 ↗
7. Tanaka, K. & Shionoya, M. Synthesis of a novel nucleoside for alternative DNA base pairing through metal complexation. J. Org. Chem. 64, 5002–5003 (1999).10.1021/jo990326u ↗
8. Tanaka, K. et al. Efficient incorporation of a copper hydroxypyridone base pair in DNA. J. Am. Chem. Soc. 124, 12494–12498 (2002).10.1021/ja027175o ↗
9. Tanaka, K., Yamada, Y. & Shionoya, M. Formation of silver(I)-mediated DNA duplex and triplex through an alternative base pair of pyridine nucleobases. J. Am. Chem. Soc. 124, 8802–8803 (2002).10.1021/ja020510o ↗
10. Clever, G. H., Polborn, K. & Carell, T. A highly DNA-duplex-stabilizing metal–salen base pair. Angew. Chem., Int. Ed. 44, 7204–7208 (2005).10.1002/anie.200501589 ↗
11. Clever, G. H. et al. Metal salen-base-pair complexes inside DNA: complexation overrides sequence information. Chem. Eur. J. DOI: 12, 8708–8718 (2006).10.1002/chem.200600558 ↗
12. Meggers, E. et al. A novel copper-mediated DNA base pair. J. Am. Chem. Soc. 122, 10714–10715 (2000).10.1021/ja0025806 ↗
13. Zimmermann, N., Meggers, E. & Schultz, P. G. A novel silver(I)-mediated DNA base pair. J. Am. Chem. Soc. 124, 13684–13685 (2002).10.1021/ja0279951 ↗
14. Weizman, H. & Tor, Y. 2,2′-Bipyridine ligandoside: a novel building block for modifying DNA with intra-duplex metal complexes. J. Am. Chem. Soc. 123, 3375–3376 (2001).10.1021/ja005785n ↗
15. Switzer, C., Sinha, S., Kim, P. H. & Heuberger, B. D. A purine-like nickel(II) base pair for DNA. Angew. Chem., Int. Ed. 44, 1529–1532 (2005).10.1002/anie.200462047 ↗
16. Kuklenyik, Z. & Marzilli, L. G. Mercury(II) site-selective binding to a DNA hairpin. Relationship of sequence-dependent intra- and interstrand cross-linking to the hairpin-duplex conformational transition. Inorg. Chem. 35, 5654–5662 (1996).10.1021/ic960260a ↗
17. Miyake, Y. et al. MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes. J. Am. Chem. Soc. 128, 2172–2173 (2006).10.1021/ja056354d ↗