journal article·2016-01-01Open access

Synthesis and functionalization of graphene and application in electrochemical biosensing

Deepshikha Saini

Nanotechnology Reviews· Volume 5· Issue 4

Abstract

Abstract Graphene is a two-dimensional material with amazing characteristics, which grant it the title “wonder material”. It has grabbed appreciable attention due to its exceptional electrical, optical, thermal, and mechanical properties. Because of these interesting properties, graphene has found its way into a wide variety of biosensing applications. It has been used as a transducer in electrochemical biosensors, bio-field-effect transistors, impedance biosensors, electrochemiluminescence, and fluorescence biosensors. Functionalization of graphene has further opened up novel fundamental and applied frontiers. The present article reviews recent works dealing with synthesis, functionalization of graphene, and its applications related to biosensors. Various synthesis strategies, mechanism and process parameters, and types of functionalization are discussed in view of biosensor development. Some potential areas for biosensor-related applications of functionalized graphene are highlighted, including catalytic biosensors and bio affinity biosensors. Wherever applicable, the limitations of the present knowledgebase and possible research directions have also been discussed.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Electrochemical sensors and biosensors · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (100+)

Show source-provided references
1. pi-H···O hydrogen bonds: multicenter covalent pi-H interaction acts as the proton-donating system10.1021/jp076990t ↗
2. Nanoelectronic biosensors based on CVD grown graphene10.1039/c0nr00142b ↗
3. Direct electrochemistry of glucose oxidase and biosensing for glucose based on graphene10.1021/ac802193c ↗
4. Graphene-based electronic sensors
5. pi-H···O hydrogen bonds: multicenter covalent pi-H interaction acts as the proton-donating system10.1021/jp076990t ↗
6. Functional composite materials based on chemically converted graphene10.1002/adma.201003753 ↗
7. Carboxymethyl chitosan-functionalized graphene for label-free electrochemical cytosensing10.1016/j.carbon.2012.08.020 ↗
8. A bottom-up approach from molecular nanographenes to unconventional carbon materials10.1039/b717585j ↗
9. Electrochemical and glucose oxidase coenzyme activity of flavin adenine dinucleotide covalently attached to glassy carbon at the adenine amino group10.1016/0304-4165(85)90250-8 ↗
10. Impedimetric immunoglobulin G immunosensor based on chemically modified graphenes10.1039/C2NR11492E ↗
11. Functionalization of graphene: covalent and non-covalent approaches, derivatives and applications10.1021/cr3000412 ↗
12. Preparation and characterization of silylated graphite oxide10.1016/j.carbon.2005.06.006 ↗
13. Epitaxial graphene10.1016/j.ssc.2007.04.023 ↗
14. The chemistry of graphene10.1039/b920539j ↗
15. Functionalized graphene sheets for polymer nanocomposites10.1038/nnano.2008.96 ↗
16. Superior thermal conductivity of single-layer graphene10.1021/nl0731872 ↗
17. Preparation, structure, and electrochemical properties of reduced graphene sheet films10.1002/adfm.200900377 ↗
18. Comprehensive energy analysis for various types of π-interaction10.1021/ct800471b ↗
19. Processing of graphene for electrochemical application: noncovalently functionalize graphene sheets with water-soluble electroactive methylene green10.1021/la9029613 ↗
20. Graphene oxide with covalently linked porphyrin antennae: synthesis, characterization and photophysical properties10.1039/C0JM00991A ↗
21. Direct electrochemistry of glucose oxidase and biosensing for glucose based on graphene10.1021/ac802193c ↗
22. Measurements of the sheet resistance and conductivity of thin epitaxial graphene and SiC films
23. Optimizing bismuth-modified graphene–carbon nanotube composite-coated screen printed electrode for lead-ion sensing through the experimental design strategy10.1149/2.081308jes ↗
24. Graphene for electrochemical sensing and biosensing10.1016/j.trac.2010.05.011 ↗
25. Flexible graphene devices related to energy conversion and storage10.1039/C4EE03685A ↗
26. Conversion of carbon dioxide to few-layer graphene10.1039/c1jm11227a ↗
27. Sudden death of entanglement10.1126/science.1167343 ↗
28. Understanding of assembly phenomena by aromatic–aromatic interactions: benzene dimer and the substituted systems10.1021/jp068635t ↗
29. Graphene, a promising transparent conductor10.1016/S1369-7021(10)70034-1 ↗
30. Electrochemical DNA biosensor with chitosan–Co3O4 nanorod–graphene composite for the sensitive detection of Staphylococcus aureus nuc gene sequence10.1016/j.bioelechem.2012.05.007 ↗
31. Effect of (L:D) aspect ratio on single polypyrrole nanowire FET device10.1021/jp104377e ↗
32. Narrow graphene nanoribbons from carbon nanotubes10.1038/nature07919 ↗
33. Synthesis and characterization of atomically thin graphite films on a silicon carbide substrate10.1016/j.jpcs.2006.05.010 ↗
34. Biological and chemical sensors based on graphene materials10.1039/C1CS15270J ↗
35. Decorated graphene-nanostructured polyaniline nanocomposite-based bienzymatic platform for cholesterol sensing10.5402/2012/102543 ↗
36. Graphene modified carbon nanosheets for electrochemical detection of Pb(II) in water10.1039/c3ta12612a ↗
37. Amperometric biosensor for NADH and ethanol based on electroreduced graphene oxide–polythioninenanocomposite film10.1016/j.snb.2013.01.072 ↗
38. Graphene sheets, polyaniline and AuNPs based DNA sensor for electrochemical determination of BCR/ABL fusion gene with functional hairpin probe10.1016/j.bios.2013.07.049 ↗
39. A novel sensitive Cu(II) and Cd(II) nanosensor platform: graphene oxide terminated p-aminophenyl modified glassy carbon surface10.1016/j.electacta.2013.09.011 ↗
40. A study on the key factors affecting the sensibility of bismuth deposits toward Sn2+: effects of bismuth microstructures on the Sn2+ pre-deposition10.1016/j.electacta.2013.04.121 ↗
41. SnO2/reduced graphene oxide nanocomposite for the simultaneous electrochemical detection of cadmium(II), lead(II), copper(II), and mercury(II): an interesting favorable mutual interference
42. Graphene bridged enzyme electrodes for glucose biosensing application10.1039/c3an36929c ↗
43. Nanostructured metal oxide-based biosensors10.1038/asiamat.2010.137 ↗
44. Platinum/graphene functionalized by PDDA as a novel enzyme carrier for hydrogen peroxide biosensor10.1039/C2AY25930C ↗
45. Large-scale pattern growth of graphene films for stretchable transparent electrodes10.1038/nature07719 ↗
46. Functionalization of graphene: covalent and non-covalent approaches, derivatives and applications10.1021/cr3000412 ↗
47. Electrochemical glucose biosensors10.1021/cr068123a ↗
48. Preparation of sulfonic-functionalized graphene oxide as ion exchange material and its application into electrochemiluminescence analysis10.1016/j.bios.2010.12.015 ↗
49. In situ synthesis of reduced graphene oxide and gold nanocomposites for nanoelectronics and biosensing10.1007/s11671-010-9806-8 ↗
50. A roadmap for graphene10.1038/nature11458 ↗
51. Impedimetric immunoglobulin G immunosensor based on chemically modified graphenes10.1039/C2NR11492E ↗
52. Water dispersible functionalized graphene fluoride with significant nonlinear optical response10.1016/j.cplett.2012.06.021 ↗
53. Functional graphene–gold nanoparticle hybrid system for enhanced electrochemical biosensing of free cholesterol10.1039/C5AY00050E ↗
54. Spectroscopy of covalently functionalized graphene10.1021/nl1021128 ↗
55. Chemical doping of graphene10.1039/C0JM02922J ↗
56. Electrochemical DNA sensors10.1038/nbt873 ↗
57. Synthesis of graphene oxide-based biocomposites through diimide-activated amidation10.1016/j.jcis.2011.01.052 ↗
58. Epitaxial graphene10.1016/j.ssc.2007.04.023 ↗
59. High-accuracy quantum mechanical studies of π–π interactions in benzene dimers10.1021/jp0610416 ↗
60. Preparation and characterization of pillared carbons obtained by pyrolysis of silylated graphite oxides10.1016/j.carbon.2008.11.040 ↗
61. Electrochemical biosensors: recommended definitions and classification10.1351/pac199971122333 ↗
62. Electrochemical sensor for transgenic maize MON810 sequence with electrostatic adsorption DNA on electrochemical reduced graphene modified electrode
63. A turn-on fluorescent copper biosensor based on DNA cleavage-dependent graphene-quenched DNAzyme10.1016/j.bios.2011.04.006 ↗
64. Reagentless glucose biosensor based on the direct electrochemistry of glucose oxidase on carbon nanotube-modified electrodes
65. Carbon nanotube purification: preparation and characterization of carbon nanotube paste electrodes10.1021/ac0300237 ↗
66. Application of graphene-modified electrode for selective detection of dopamine10.1016/j.elecom.2009.02.013 ↗
67. Highly exposed {001} facets of titanium dioxide modified with reduced graphene oxide for dopamine sensing10.1038/srep05044 ↗
68. On the importance of electron correlation effects for the π-π interactions in cyclophanes10.1002/chem.200400091 ↗
69. Flexible graphene devices related to energy conversion and storage10.1039/C4EE03685A ↗
70. An enzymatic biosensor for hydrogen peroxidebased on one-pot preparation of CeO2-reducedgraphene oxide nanocomposite10.1039/C4RA12841A ↗
71. Nickel-functionalized reduced graphene oxide with polyanilinefor non-enzymatic glucose sensing10.1007/s00604-014-1366-7 ↗
72. Carbon nanotube purification: preparation and characterization of carbon nanotube paste electrodes10.1021/ac0300237 ↗
73. Photoluminescent graphene oxide microarray for multiplex heavy metal ion analysis10.1002/smll.201300499 ↗
74. Origin of the high affinity and selectivity of novel receptors for NH4+ over K+: charged hydrogen bonds vs cation–π interaction10.1021/ol000159g ↗
75. Covalent functionalization of epitaxial graphene by azidotrimethylsilane10.1021/jp9010444 ↗
76. Large-area chemically modified graphene films: electrophoretic deposition and characterization by soft X-ray absorption spectroscopy10.1021/cm901554p ↗
77. Decorated graphene-nanostructured polyaniline nanocomposite-based bienzymatic platform for cholesterol sensing10.5402/2012/102543 ↗
78. Synthesis of graphene oxide-based biocomposites through diimide-activated amidation10.1016/j.jcis.2011.01.052 ↗
79. DNA biosensors and microarrays10.1021/cr0684467 ↗
80. Graphene sheets, polyaniline and AuNPs based DNA sensor for electrochemical determination of BCR/ABL fusion gene with functional hairpin probe10.1016/j.bios.2013.07.049 ↗
81. A sensitive electrochemical DNA biosensor based on gold nanomaterial and graphene amplified signal10.1016/j.snb.2014.04.024 ↗
82. Graphene-based biosensors for detection of bacteria and their metabolic activities10.1039/c1jm11436k ↗
83. Signal amplification for electrochemical DNA biosensor based on two-dimensional graphene analogue tungsten sulfide–graphene composites and gold nanoparticles10.1016/j.snb.2013.10.072 ↗
84. Graphene, a promising transparent conductor10.1016/S1369-7021(10)70034-1 ↗
85. Controlling the electronic structure of bilayer graphene10.1126/science.1130681 ↗
86. Solvent-driven structural changes in anion–π complexes10.1021/ct8001283 ↗
87. Electrochemical DNA biosensor with chitosan–Co3O4 nanorod–graphene composite for the sensitive detection of Staphylococcus aureus nuc gene sequence10.1016/j.bioelechem.2012.05.007 ↗
88. Graphene-DNAzyme based biosensor for amplified fluorescence turn-on detection of Pb2+ with a high selectivity10.1021/ac200843x ↗
89. Enzymatic electrochemical glucose biosensors by mesoporous 1D hydroxyapatite-on-2D reduced graphene oxide10.1039/C4TB01651C ↗
90. Graphenes as potential material for electronics10.1021/cr068010r ↗
91. Highly sensitive protein sensor based on thermally reduced graphene oxide field-effect transistor10.1007/s12274-011-0148-3 ↗
92. Electrochemiluminescence biosensor for glucose based on graphene/nafion/GOD film modified glassycarbon electrode10.1002/elan.201000095 ↗
93. Graphene and graphene oxide: synthesis, properties, and applications10.1002/adma.201001068 ↗
94. Graphene for electrochemical sensing and biosensing10.1016/j.trac.2010.05.011 ↗
95. Electrochemical biosensors: recommended definitions and classification10.1351/pac199971122333 ↗
96. One-pot functionalization of graphene with porphyrin through cycloaddition reactions10.1002/chem.201100980 ↗
97. Graphene-based supercapacitor with an ultrahigh energy density10.1021/nl102661q ↗
98. Preparation of sulfonic-functionalized graphene oxide as ion exchange material and its application into electrochemiluminescence analysis10.1016/j.bios.2010.12.015 ↗
99. Electric field effect in atomically thin carbon films10.1126/science.1102896 ↗
100. Ultrafine palladium nanoparticles grown on graphene nanosheets for enhanced electrochemical sensing of hydrogen peroxide10.1016/j.electacta.2013.02.047 ↗