DataVXACS Applied Materials & InterfacesPaper
journal article·2026-07-01

Fingertip Sweat Leucine Detection Based on Electrochemical MIP Sensors Integrated with Porous Hydrogels

Xiaoman Wei, Xuezheng Hou, Hui Zhang, Hanjie Wang, Lei Wang, Huanyu Cheng, Li Yang

ACS Applied Materials & Interfaces· Volume 18· Issue 25
Publisher page
Source abstract

Abstract

Leucine (Leu) is a promising biomarker for metabolic health and muscle growth, offering significant potential for assessing physical well-being. Sweat sensors for Leu detection eliminate the reliance on invasive blood analysis and the sophisticated, large-scale instrumentation. Current sweat sensors, however, are complex to fabricate, exhibit low sensitivity toward nonelectroactive Leu, require intense exercise or thermal/chemical stimulation to generate sweat, and lack reusability. This work reports a flexible, highly sensitive, and reusable sweat sensor based on molecularly imprinted polymers, Prussian blue nanoparticles, and laser-induced graphene. When integrated with a highly permeable porous Poly(vinyl alcohol) hydrogel for convenient and rapid collection of instantaneous sweat secreted from the fingertip, the sensor can continuously detect Leu with high sensitivity (7641 nA mm-2 per decade), low detection limit (10 nM), and excellent repeatability. This flexible biosensing patch offers a promising strategy for noninvasive sweat Leu analysis and wearable health monitoring, showing potential for assessing health status related to obesity, type 2 diabetes (T2DM), and muscle loss.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

PolymersNanomaterials

OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Polydiacetylene-based materials and applications · Advanced Chemical Sensor Technologies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Health Sciences and Biomedical Engineering

Hebei University of Technology

State Key Laboratory of Reliability and Intelligence of Electrical Equipment, School of Electrical Engineering

Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences

Hainan University

Biomedical Engineering

Chinese Academy of Medical Sciences & Peking Union Medical College

Department of Engineering Science and Mechanics

The Pennsylvania State University

Funding

Natural Science Foundation of Hebei Province · Natural Science Foundation of Tianjin Municipality · China Postdoctoral Science Foundation · Pennsylvania State University · National Natural Science Foundation of China · National Institutes of Health · National Science Foundation · Hebei Provincial Department of Science and Technology

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