journal article·2026-05-27Open access

Infrared Near-Field Microscopy as a Platform for Nanoscale Biomedical Spectroscopy and Imaging

Hongcai Deng, Xin Zhao, Xinyue Na, Ankang Liu, Ruofan Cheng, Fantao Jiang, Qi Zhang, Fengwei Gao, Hong Wu, Ting Zhang, Weiliang Ma, Longjiang Deng

ACS Applied Materials & Interfaces· Volume 18· Issue 20

Abstract

Precision medicine requires tools that can resolve molecular information at the nanoscale, where many early biological and pathological changes arise. Scanning near-field optical microscopy (SNOM) combines molecular vibrational fingerprints with nanoscale spatial resolution, providing a unique platform for overcoming the diffraction limit of conventional optics and enabling in situ chemical characterization of biological samples. This paper systematically reviews the development of SNOM from near-field imaging to spectroscopic platforms such as nano-FTIR and AFM-IR, and summarizes the latest advances in ultrafast, liquid-phase, terahertz, and miniaturized systems. Focusing on representative studies involving proteins, nucleic acids, bacteria, viruses, extracellular vesicles, and cell-material interfaces, this paper discusses SNOM's ability to resolve molecular heterogeneity, structural transitions, and local biochemical interactions in near-natural environments. Additionally, the article analyzes the major challenges facing its clinical translation, including sample preparation, signal-to-noise ratio, measurement speed, quantitative analysis, and standardization, and explores its application potential in AI-assisted analysis, portability, and neuroscience. SNOM is expected to become a key technological platform bridging molecular diagnostics and nanobiological imaging.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Near-Field Optical Microscopy · Plasmonic and Surface Plasmon Research · Gold and Silver Nanoparticles Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

National Engineering Research Center of Electromagnetic Radiation Control Materials University of Electronic Science and Technology of China

Key Laboratory of Multi-spectral Absorbing Materials and Structures of Ministry of Education

University of Electronic Science and Technology of China

Laboratory of Hepatic AI Translation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital

Sichuan University

Department of General Surgery, West China Hospital

College of Biological and Chemical Engineering

Qilu Institute of Technology

Liver Transplant Center, Transplant Center, West China Hospital

Funding

West China Hospital, Sichuan University · National Key Research and Development Program of China · University of Electronic Science and Technology of China · Ministry of Finance · Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China

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