Building an Electrochemical Sensor Platform: Metal Tellurate-Decorated 2D Boron Nitride for Ornidazole Detection

The creation of 2D-based nanoparticles on the surface of glassy carbon electrodes (GCE) optimizes electrocatalytic activity by virtue of their size, elevated active surface area, and defective sites. Ornidazole (ODZ) is a therapeutic molecule that is detected at the micromolar level using metal tellurate loaded on boron nitride on GCE. The physicochemical properties of synthetic materials were characterized using a variety of microscopic and spectroscopic techniques. As a result of these studies, metal tellurate loaded on boron nitride on GCE was made solely and with the greatest response. Additionally, modified GCE shows higher reduction behavior at ambient temperature with an optimal working buffer pH of 7.0. A novel metal tellurate loaded on a boron nitride-modified glassy carbon electrode (GCE) was developed for ultrasensitive micromolar detection of ornidazole. The sensor achieves a record-LOD of 0.002 μM, wide linearity (0.04-156.18 μM), and exceptional selectivity and stability in real samples. This platform significantly outperforms existing boron nitride- and metal tellurate-based sensors for ornidazole analysis. Unlike previously reported sensors employing single-metal tellurates or carbon materials, the present work introduces a 2D sheet-derived metal tellurate, offering enhanced electroactive sites.