journal article·2024

From sensing interactions to controlling the interactions: a novel approach to obtain biological transistors for specific and label-free immunosensing

Soumadri Samanta, Vinay S. Tiwari, Sumesh Sadhujan, Sherina Harilal, Avital Eisenberg-Lerner, Ziv Rotfogel, Evgeny Pikhay, Ruth Shima-Edelstein, Doron Greental, Muhammad Y. Bashouti, Barak Akabayov, Izhar Ron, Yakov Roizin, Offer Erez, Gil Shalev

Nanoscale· Volume 16· Issue 13
Publisher page

Abstract

-nano-channel (MNC) BioFET and demonstrate how the solution electrode can determine the antibody-antigen equilibrium constant and allows the control and tuning of the sensing performance in terms of the dynamic range and limit-of-detection. In the current work, we employed this method to demonstrate the specific and label-free sensing of Alpha-Fetoprotein (AFP) molecules from 0.5 μL drops of 1 : 100 diluted serum. AFP was measured during pregnancy as part of the prenatal screening program for fetal anomalies, chromosomal abnormalities, and abnormal placentation. We demonstrate AFP sensing with a limit-of-detection of 10.5 aM and a dynamic range of 6 orders of magnitude in concentration. Extensive control measurements are reported.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Analytical Chemistry and Sensors · Advanced biosensing and bioanalysis techniques · Microfluidic and Bio-sensing Technologies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Electrical Engineering, Ben-Gurion University of the Negev, Israel

Department of Chemistry and Data Science Research Center, Ben-Gurion University of the Negev, 8410501, Beer-Sheva, Israel

Department of Solar Energy and Environmental Physics, Swiss Institute for Dryland Environmental and Energy Research, J. Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Midreshet Ben-Gurion 8499000, Israel

Ophthalmology Research Laboratory, Kaplan Medical Center, Rehovot, Israel

Faculty of Medicine, Hadassah Medical School, The Hebrew University of Jerusalem, Jerusalem, Israel

Tower Semiconductor, PO Box 619, Migdal Haemek, Israel

The Ilse-Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, POB 653, Beer-Sheva 8410501, Israel

Department of obstetrics and Gynecology Soroka University Medical Center, School of Medicine, Ben Gurion University of the Negev, Beer Sheva, Israel

Department of Obstetrics and Gynecology, School of Medicine, Wayne State University, Detroit, MI, USA

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