DataVXACS Applied Materials & InterfacesPaper
journal article·2026-03-18

Redox-Triggered Autologous Protein Assembly for Blood-Contacting Interfaces

Mengjie Li, Yuhang Zhang, Yongchun Liu, Jinglin Wang, Man Zhang, Shuting Miao, Juanhua Tian, Fei Tao, Lihua Tian, Ke Li, Peng Yang

ACS Applied Materials & Interfaces· Volume 18· Issue 10
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Source abstract

Abstract

Bioresources offer essential biological functionality for biomedical applications, yet their clinical translation is limited by a fundamental dilemma: in conventional allogeneic host-to-patient (A–B) designs, stringent pathogen-removal processes often inactivate the very biomolecules that provide function while introducing risks of immunogenicity and contamination. To resolve this, we introduce a ligand dissociation-induced phase-transition strategy to construct hemoglobin-based ultrathin biocoatings, enabling a robust autologous-to-autologous (A–A) route. Mild reductant-initiated redox-triggered assembly enabled hemoglobin directly extracted from the patient’s own blood to self-organize into nanoscale films without harsh chemical treatments. This high-efficiency process allows 1 mL of blood to functionalize ∼0.9 m 2 of diverse substrates, creating coatings that are not only structurally robust and antibiofouling but also capable of coassembling with heparin. The resulting composite significantly prolongs activated partial thromboplastin time (>600 s) with reduced systemic toxicity while also eliminating cross-individual transmission risk, establishing a clinically translatable paradigm for personalized, blood-contacting medical devices.
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Research context

NanomaterialsComposites

OpenAlex topics: Polymer Surface Interaction Studies · Biochemical and Structural Characterization · Bacteriophages and microbial interactions

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering

Shaanxi Normal University

Xi’an Key Laboratory for Prevention and Treatment of Common Aging Diseases, Institute of Basic and Translational Medicine

Xi’an Medical University

Department of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Tianjin Nankai Hospital, Nankai Clinical School of Medicine, Tianjin Medical University, 6 Changjiang Road, Nankai District, Tianjin 300100, China

School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Eastern HuaLan Avenue, Xinxiang, Henan 453003, China

Engineering Research Center of Conservation, Development and Utilization of Characteristic Biological Resources in Hanjiang River Basin

College of Life Science, Jianghan University

Funding

Natural Science Basic Research Program of Shaanxi Province · Shaanxi Key Science and Technology Innovation Team Project · National Science Fund for Distinguished Young Scholars · Fundamental Research Funds for the Central Universities · Higher Education Discipline Innovation Project · Key Research and Development Projects of Shaanxi Province · Major Scientific and Technological Achievements Commercialization Project · Shaanxi Innovative Research and Development Institution · International Science and Technology Cooperation Program of Shaanxi Province · Xi'an Association for Science and Technology-Young Talent Fostering Plan · Qinchuangyuan Scientists and Engineers Team Development · National Basic Research Program of China (973 Program) · Key Projects-Critical and Core Technology Breakthroughs-Agriculture and Rural Sector · Key Projects-Critical and Core Technology Breakthroughs-Social Development Sector · Key Technology Breakthrough Project for Priority Agricultural Industrial Chains · National Natural Science Foundation of China (NSFC)

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