A Multiterminal Neuromorphic Biodevice Based on Biocompatible Quaternized Chitosan by Biomimicking Synaptic Integration and the Visual Nervous Processor System

The growing computational bottleneck of von Neumann systems underscores the urgent need for a brain-inspired, energy-efficient approach. In response, a fully biocompatible multiterminal neuromorphic biodevice was developed using an acellular dermal matrix (ADM) as a biocompatible substrate, polylactic acid (PLA) as an insulator, quaternized chitosan (QCS) as a functional layer, and Au metal as electrodes while eliminating biological rejection risks. Operating at ultralow voltages (≤5 mV), the biodevice reproduces complex neurodynamic spatial integration processes, surpassing conventional two-terminal designs and enabling the simulation of the visual nervous processor system in the context of light adaptation. Different visual receptive fields were also studied. This work provides a feasible strategy for high-performance biohybrid computing systems with minimal power consumption and further functional biomimicry.