Alendronate-Based Polypeptide Hydrogels with Osteogenic Potential for Digital Light Processing
Source abstract
Abstract
In this work, we present an alendronate star polypeptide formulation capable of digital light processing high-resolution 3D hydrogel structures. Through the use of embedded bisphosphonate moieties from the alendronate, which has a high affinity for divalent calcium (Ca 2+ ) ions, a second ionic network is introduced within the hydrogel. A significant enhancement of hydrogel mechanical properties is observed, reaching Young’s modulus values toward those observed for native bone. Furthermore, the presence of Ca 2+ supports mineralization, fostering osteogenesis in seeded rat mesenchymal stem cells (rMSCs), indicating the potential to promote effective bone tissue regeneration.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Hydrogels: synthesis, properties, applications · Supramolecular Self-Assembly in Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry
RCSI University of Medicine and Health Science
Tissue Engineering Research Group, Department of Anatomy and Regenerative Medicine
RCSI University of Medicine and Health Sciences
The SFI Centre for Advanced Materials and BioEngineering Research
Trinity Centre for Biomedical Engineering
Trinity College Dublin
CURAM the SFI Research Centre for Medical Devices, Department of Chemistry
Funding
Science Foundation Ireland
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