DataVXACS Applied Materials & InterfacesPaper
journal article·2025-10-15

An Electrical Stimulation-Driven Strategy for Peroxide-like Enzyme Reactivation toward Sustainable Wastewater Sterilization

Jingyang Fang, Guopeng Xu, Paul K. Chu, Jianzhong Du, Guomin Wang

ACS Applied Materials & Interfaces· Volume 17· Issue 41
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Source abstract

Abstract

Metal-based enzyme mimics face irreversible deactivation due to the oxidation of active metal centers, limiting their sustainability in wastewater treatment. To meet this important challenge, we introduce an electrical stimulation strategy by designing Fe-doped titanium dioxide nanolines (Fe-TNLs) that mimic peroxidase (POD) activity and regenerate catalytic function, enabling enzyme reuse. The Fe-TNLs exhibit robust POD-like activity by catalyzing the decomposition of H 2 O 2 into hydroxyl radicals ( • OH), achieving over 99.9% inactivation against Escherichia coli and Staphylococcus aureus during the initial cycle. Unlike conventional Fe-based POD mimics, which are rapidly deactivated due to the oxidation of Fe(II) to Fe(III), this system achieves a reversible Fe(III)/Fe(II) redox cycle through electrical charging, restoring over 80% of the initial catalytic efficiency. Moreover, the reactivated Fe-TNLs maintain effective performance in simulated wastewater and retain approximately 60% of their initial efficacy after reactivation, outperforming single-use systems. By emphasizing sustainable reusability over single-use designs, this work offers a compelling approach for advancing environmentally friendly wastewater remediation technologies.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Electrochemical sensors and biosensors · Advanced Nanomaterials in Catalysis · Biosensors and Analytical Detection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, 4800 Caoan Road, Shanghai 201804, China

State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center, Shanghai East Hospital, Department of Cardiovascular Surgery, Shanghai Tenth People’s Hospital, School of Medicine

Tongji University

Department of Physics, Department of Materials Science and Engineering and Department of Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong 999077, China

Department of Gynaecology and Obstetrics, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine

Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, School of Materials Science and Engineering

School of Materials Science and Engineering

East China University of Science and Technology

Funding

Natural Science Foundation of Shanghai Municipality · National Key Research and Development Program of China · Shanghai Municipal Education Commission · Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China

References (69)

Show source-provided references
1. 10.1038/s41565-018-0203-210.1038/s41565-018-0203-2 ↗
2. 10.1016/S1473-3099(15)00424-710.1016/S1473-3099(15)00424-7 ↗
3. 10.1016/S0140-6736(21)02724-010.1016/S0140-6736(21)02724-0 ↗
4. 10.1016/j.ajic.2019.01.01410.1016/j.ajic.2019.01.014 ↗
5. 10.1021/acsestengg.1c0033010.1021/acsestengg.1c00330 ↗
6. 10.1016/j.seppur.2024.12709210.1016/j.seppur.2024.127092 ↗
7. 10.1016/j.apcatb.2025.12521810.1016/j.apcatb.2025.125218 ↗
8. 10.1016/j.molliq.2018.12.01110.1016/j.molliq.2018.12.011 ↗
9. 10.1002/smll.20200681310.1002/smll.202006813 ↗
10. 10.1002/adma.20170418110.1002/adma.201704181 ↗
11. 10.1073/pnas.240384212110.1073/pnas.2403842121 ↗
12. 10.1016/j.ijbiomac.2023.12405110.1016/j.ijbiomac.2023.124051 ↗
13. 10.1016/j.cjche.2020.04.01010.1016/j.cjche.2020.04.010 ↗
14. 10.1016/j.biotechadv.2023.10821910.1016/j.biotechadv.2023.108219 ↗
15. 10.3390/jcs712048810.3390/jcs7120488 ↗
16. 10.1016/j.jece.2018.11.04910.1016/j.jece.2018.11.049 ↗
17. 10.1021/acsnano.7b0476610.1021/acsnano.7b04766 ↗
18. 10.3390/biom1205059910.3390/biom12050599 ↗
19. 10.1016/j.talanta.2024.12600310.1016/j.talanta.2024.126003 ↗
20. 10.1016/j.cej.2021.13243610.1016/j.cej.2021.132436 ↗
21. 10.1002/advs.20230715410.1002/advs.202307154 ↗
22. 10.1021/acscatal.5c0096110.1021/acscatal.5c00961 ↗
23. 10.1016/j.talanta.2025.12817910.1016/j.talanta.2025.128179 ↗
24. 10.1016/j.nantod.2023.10202510.1016/j.nantod.2023.102025 ↗
25. 10.1016/j.cej.2024.15570610.1016/j.cej.2024.155706 ↗
26. 10.1038/s41467-018-04317-210.1038/s41467-018-04317-2 ↗
27. 10.1038/nrmicro302810.1038/nrmicro3028 ↗
28. 10.1021/acs.langmuir.8b0016310.1021/acs.langmuir.8b00163 ↗
29. 10.1021/ja505562p10.1021/ja505562p ↗
30. 10.1016/j.electacta.2016.11.10810.1016/j.electacta.2016.11.108 ↗
31. 10.1038/s41467-022-33098-y10.1038/s41467-022-33098-y ↗
32. 10.1021/cm00008a02110.1021/cm00008a021 ↗
33. 10.1039/C6EN00398B10.1039/C6EN00398B ↗
34. 10.1016/j.biomaterials.2020.12053710.1016/j.biomaterials.2020.120537 ↗
35. 10.1038/s42004-023-00865-x10.1038/s42004-023-00865-x ↗
36. 10.1021/acsanm.4c0336310.1021/acsanm.4c03363 ↗
37. 10.1021/acscatal.3c0099410.1021/acscatal.3c00994 ↗
38. 10.1016/j.pnsc.2024.05.01010.1016/j.pnsc.2024.05.010 ↗
39. 10.1016/j.apcatb.2016.11.02310.1016/j.apcatb.2016.11.023 ↗
40. 10.1021/acscatal.6b0317010.1021/acscatal.6b03170 ↗
41. 10.1038/s41596-018-0001-110.1038/s41596-018-0001-1 ↗
42. 10.1080/15592324.2015.101091710.1080/15592324.2015.1010917 ↗
43. 10.1126/sciadv.ado555510.1126/sciadv.ado5555 ↗
44. 10.1006/abbi.1993.107410.1006/abbi.1993.1074 ↗
45. 10.1126/sciadv.adg960110.1126/sciadv.adg9601 ↗
46. 10.1002/anie.20231801110.1002/anie.202318011 ↗
47. 10.1039/D3MH01102J10.1039/D3MH01102J ↗
48. 10.1016/j.jcis.2022.08.07310.1016/j.jcis.2022.08.073 ↗
49. 10.1021/acsabm.2c0018310.1021/acsabm.2c00183 ↗
50. 10.1039/D2BM01341J10.1039/D2BM01341J ↗
51. OECD · 200110.1787/9789264070424-en ↗
52. 10.1016/j.ijbiomac.2025.14640510.1016/j.ijbiomac.2025.146405 ↗
53. 10.1007/s40820-024-01522-110.1007/s40820-024-01522-1 ↗
54. 10.1016/j.watres.2021.11798410.1016/j.watres.2021.117984 ↗
55. 10.1016/j.cej.2021.13001210.1016/j.cej.2021.130012 ↗
56. 10.1016/j.cej.2019.04.19510.1016/j.cej.2019.04.195 ↗
57. 10.1016/j.psep.2022.10.08310.1016/j.psep.2022.10.083 ↗
58. 10.1016/j.cej.2015.06.11510.1016/j.cej.2015.06.115 ↗
59. 10.1016/j.watres.2025.12348910.1016/j.watres.2025.123489 ↗
60. 10.1002/adma.20250117410.1002/adma.202501174 ↗
61. 10.1016/j.jhazmat.2018.03.05510.1016/j.jhazmat.2018.03.055 ↗
62. 10.1016/j.chemosphere.2007.02.01510.1016/j.chemosphere.2007.02.015 ↗
63. 10.1021/cm303411t10.1021/cm303411t ↗
64. 10.1038/s41598-019-45127-w10.1038/s41598-019-45127-w ↗
65. 10.1038/s41598-019-45127-w10.1038/s41598-019-45127-w ↗
66. 10.1038/nchembio.8510.1038/nchembio.85 ↗
67. 10.1016/j.ecoenv.2023.11556410.1016/j.ecoenv.2023.115564 ↗
68. 10.1038/s41545-023-00245-x10.1038/s41545-023-00245-x ↗
69. 10.1201/9781003165958-1610.1201/9781003165958-16 ↗