Engineered Nanomaterials at Physiologically Relevant Doses Promote Keratinocyte Migration via Induction of Autophagy- and Redox-Dependent Pathways
Source abstract
Abstract
The proliferating incorporation of engineered nanomaterials (ENMs) in everyday consumer products, such as sunscreen, poses concerns about the dermal exposure effects of these ENMs. Well-characterized ENMs, titanium dioxide and zinc oxide, are utilized as models to understand ENM interactions with skin cells and their influence on wound closure. The ENMs, at relevant exposure doses, have been demonstrated to promote the wound closure process in both in vitro and ex vivo skin explant models. Mechanistic studies reveal that the wound closure process is modulated by intracellular ROS production, with the involvement of autophagy, JNK, and ERK signaling pathways, to promote ENM-induced focal adhesion turnover, microtubule remodeling, and cell migration.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Wound Healing and Treatments · Autophagy in Disease and Therapy · Nanoparticles: synthesis and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
Plastic, Reconstructive and Aesthetic Surgery Service, Department of General Surgery, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
Skin Research Institute of Singapore, Biomedical Science Institutes, Immunos, 8A Biomedical Grove, Singapore 138648, Singapore
Nanyang Environment & Water Research Institute, CleanTech One, 1 Cleantech Loop, Singapore 637141, Singapore
Funding
School of Materials Science and Engineering, Nanyang Technological University
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