DataVXACS Applied Materials & InterfacesPaper
journal article·2025-09-10

Self-Adaptive Sn–Fe Electron Pair Centers in Pt/SnFe2O4 for Anti-Tumor Synergistic Therapy

Meichun Fu, Zhiyu Shao, Yuan Zhang, Qian Zhu, Kuo He, Mengzhu Zhang, Yuzhu Hou, Laiping Fang, Fei Yan, Shuang Zhang, Jianshi Du, Ping’an Ma, Keke Huang, Shouhua Feng

ACS Applied Materials & Interfaces· Volume 17· Issue 36
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Source abstract

Abstract

Despite the multiple advantages of high tissue penetration depth, selectivity, and noninvasiveness of photothermal-assisted antitumor synergistic therapy, developing photothermal agents with multifunctional characteristics, desirable tumor therapeutic effects, and biological stability remains a key challenge. Herein, an electronic structure-regulated strategy is proposed to activate self-adaptive Sn–Fe electron pair centers (Sn 2+ /Sn 4+ and Fe 2+ /Fe 3+ ) through loading the electron donor Pt (Pt/SFO-1, -2, -3, -4). Experimental and theoretical calculations indicate that abundant dynamic active centers can facilitate the production of reactive oxygen species (ROS), which enables Pt/SFO samples to possess catalase (CAT), peroxidase (POD), and oxidase (OXD) enzyme-like activities. Upon near-infrared (NIR) laser irradiation, Pt/SFO-2 with a Pt load of 0.9% achieves the highest ROS production, showing a 9-fold compared with SnFe 2 O 4 and implements the synergistic therapy of photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy (CDT). The electronic state regulation of inorganic photothermal agents not only improves tumor therapeutic effects but also offers a novel strategy to regulate the electron structure of active centers.
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Research context

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin Provincial International Cooperation Key Laboratory of Advanced Inorganic Solid Functional Materials, College of Chemistry

Jilin University

China-Japan Union Hospital of Jilin University

Key Laboratory of Lymphatic Surgery of Jilin Province

Engineering Laboratory of Lymphatic Surgery of Jilin Province

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry

Chinese Academy of Sciences

Jilin Ginseng Academy

Changchun University of Chinese Medicine

Guangdong Second Provincial General Hospital, Postdoctoral Research Station of Basic Medicine, School of Medicine, Jinan University, Xingangzhong Road 466, Guangzhou 518037, P. R. China

Healthcare Department

Affiliated Hospital of Changchun University of Traditional Chinese Medicine

Funding

Natural Science Foundation of Jilin Province · National Key Research and Development Program of China · Jilin University · Department of Science and Technology of Jilin Province · National Natural Science Foundation of China

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