DataVXACS Applied Materials & InterfacesPaper
journal article·2024-06-12

Virological and Mitochondriopathogical Characteristics of the SARS-CoV-2 Omicron XBB.1.16 Spike

Liaoxin Fang, Xiaofeng Kang, Qian Hong, Chunyuan Xue, Lu Pan, Jiaxin Chen, Chuanhao Tang, Liying Sun, Xiaojie Xu, Jing Yuan, Yimeng Du, An Xu

ACS Applied Materials & Interfaces· Volume 16· Issue 23
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Source abstract

Abstract

The emergence of XBB.1.16 has gained rapid global prominence. Previous studies have elucidated that the infection of SARS-CoV-2 induces alterations in the mitochondrial integrity of host cells, subsequently influencing the cellular response to infection. In this study, we compared the differences in infectivity and pathogenicity between XBB.1.16 and the parental Omicron sublineages BA.1 and BA.2 and assessed their impact on host mitochondria. Our findings suggest that, in comparison with BA.1 and BA.2, XBB.1.16 exhibits more efficient spike protein cleavage, more efficient mediating syncytia formation, mild mitochondriopathy, and less pathogenicity. Altogether, our investigations suggest that, based on the mutation of key sites, XBB.1.16 exhibited enhanced infectivity but lower pathogenicity. This will help us to further investigate the biological functions of key mutation sites.
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Research context

OpenAlex topics: SARS-CoV-2 and COVID-19 Research · COVID-19 Clinical Research Studies · PARP inhibition in cancer therapy

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Genetic Engineering, Beijing Institute of Biotechnology, Beijing 100071, China

Affiliated Huaihai Hospital of Xuzhou Medical University/71st Group Army Hospital of CPLA Army, Xuzhou 221004, Jiangsu,China

Department of Bacteriology, Capital Institute of Pediatrics, Beijing 100020, China

Department of Oncology, The Second Medical Center of Chinese PLA General Hospital, Beijing 100853, China

Funding

National Key Research and Development Program of China · Natural Science Foundation of Beijing Municipality · Beijing high-level public health technical talent project · General Hospital of People's Liberation Army · Laboratory of Advanced Biotechnology · National Defense Biotechnology Fund for Outstanding Young Talents

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