journal article·2023-09-26

Selective Cell–Cell Adhesion Regulation via Cyclic Mechanical Deformation Induced by Ultrafast Nanovibrations

Young Ju Son, Changjoon Keum, Minsoo Kim, Goeen Jeong, Soyeong Jin, Hae Won Hwang, Hyewon Kim, Kyungwoo Lee, Hojeong Jeon, Hojun Kim, Ki Joo Pahk, Ho Won Jang, Jeong-Yun Sun, Hyung-Seop Han, Kwan Hyi Lee, Myoung-Ryul Ok, Yu-Chan Kim, Youngdo Jeong

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Abstract

The adoption of dynamic mechanomodulation to regulate cellular behavior is an alternative to the use of chemical drugs, allowing spatiotemporal control. However, cell-selective targeting of mechanical stimuli is challenging due to the lack of strategies with which to convert macroscopic mechanical movements to different cellular responses. Here, we designed a nanoscale vibrating surface that controls cell behavior via selective repetitive cell deformation based on a poroelastic cell model. The vibrating indentations induce repetitive water redistribution in the cells with water redistribution rates faster than the vibrating rate; however, in the opposite case, cells perceive the vibrations as a one-time stimulus. The selective regulation of cell-cell adhesion through adjusting the frequency of nanovibration was demonstrated by suppression of cadherin expression in smooth muscle cells (fast water redistribution rate) with no change in vascular endothelial cells (slow water redistribution rate). This technique may provide a new strategy for cell-type-specific mechanical stimulation.
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Research context

OpenAlex topics: Cellular Mechanics and Interactions · 3D Printing in Biomedical Research · Force Microscopy Techniques and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center for Biomaterials, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea

Center for Advanced Biomolecular Recognition, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea

Department of Chemistry, Hanyang University, Seoul 04763, Republic of Korea

Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea

KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea

Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea

Department of Biomedical Engineering, Kyung Hee University, Yongin 17104, Republic of Korea

Department of HY-KIST Bio-convergence, Hanyang University, Seoul 04763, Republic of Korea

Funding

KU-KIST Graduate School of Converging Science and Technology · National Research Foundation of Korea · Korea Institute of Science and Technology · National NanoFab Center

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