Assembly of Silver Nanoparticle on One-Dimensional Supramolecular Scaffolds for Bacterial Infection Treatment

Bacterial antibiotic resistance has emerged as a major global threat to human health. The rapid spread of multidrug-resistant bacteria severely limits therapeutic and diagnostic options in clinical practice. Silver nanoparticles (Ag NPs) exhibit potent antibacterial activity due to their unique antimicrobial mechanisms. However, their tendency to aggregate in bodily fluids significantly compromises their efficacy. To overcome this limitation, we developed supramolecular scaffold-based assemblies of Ag NPs. Specifically, we utilized molecular assemblies as soft templates to guide the directional organization of Ag NPs into one-dimensional nanostructures. The resulting TPE/Ag assemblies demonstrated excellent biocompatibility, while effectively suppressing inflammation and promoting tissue repair in MRSA-infected deep skin wounds. Both in vitro and in vivo antibacterial assays confirmed their exceptional germicidal activity, which was attributed to enhanced reactive oxygen species generation and controlled silver ion release. Moving forward, TPE/Ag assemblies may represent a promising strategy for developing novel biological therapies for the treatment of infectious diseases.