Self-assembling Depsipeptides on Aggregation-Induced Emission Luminogens: A New Way to Create Programmable Nanovesicles and Soft Nanocarriers
Source abstract
Abstract
We introduce the proof of concept of a new methodology to produce robust hollow nanovesicles stable in water or mixtures of water and organic solvents. The bottom-up produced nanovesicles are formed by the self-assembly of depsipeptide chains of natural origin combined with new aggregation-induced emission luminogens that function as constitutional vesicle-forming moieties and fluorescent indicators of the structure of the nanovesicle. The newly formed nanovesicles are robust enough to be used to carry large molecules such as physiological peptides without losing their structural characteristics, acting as programmable nanocarrier systems within living cells as Trojan horse systems, constituting a new approach to active transport and nanoencapsulation.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Luminescence and Fluorescent Materials · Supramolecular Self-Assembly in Materials · Molecular Sensors and Ion Detection
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry, Faculty of Science
University of Burgos
Department of Health Science, Faculty of Health Science
Instituto de Biomedicina y Genética Molecular (IBGM)
Consejo Superior de Investigaciones Científicas (CSIC) y Universidad de Valladolid
Instituto de Química Avanzada de Cataluña (IQAC−CSIC), Jordi Girona 18-26, Barcelona 08034, Spain
LTI, I+D Uvainnova-Campus Miguel Delibes
University of Valladolid
STEBICEF Department
Università degli Studi di Palermo
Department of Chemistry
Durham University
Funding
Ministerio de Ciencia, Innovaci?n y Universidades
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