Analysis of Tribological and Cytotoxicity Assays of a Biocompatible Mg–Zn–Ca–Pr Alloy
Source abstract
Abstract
This work covers a Mg-Zn-Ca-Pr alloy fabricated by a novel method of mechanical alloying and spark plasma sintering (SPS). Currently, magnesium alloys used as biomaterials are mostly commercial alloys without consideration of cytotoxicity from the perspective of biosafety. So far, the tribological and cytotoxic properties of Mg-Zn-Ca-Pr alloys have not been investigated. Hence, in the article, the tribological properties, considering wear rate, wear resistance, coefficient of friction, and the roughness of the sintered Mg-Zn-Ca-Pr alloy, are investigated. Cytotoxicity assays have also been carried out. The ball-on-a-disc method is used in the tribological test. Samples before sintering by the SPS method are milled at varying times of 13, 20, and 70 h. Results show that increasing the milling time affects tribology and cytotoxic tests. The longer the milling time, the lower the cell survival rate. The conducted tests reveal cell survival of 90, 82, and 61% for 13, 20, and 70 h, respectively. A reduction of cell viability by over 30% is considered a cytotoxic effect, which was observed only in the 70 h milling-time samples.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Magnesium Alloys: Properties and Applications · Metal and Thin Film Mechanics · Aluminum Alloys Composites Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Engineering Materials and Biomaterials, Faculty of Mechanical Engineering, Silesian University of Technology, 44-100 Gliwice, Poland
Faculty of Mechatronics and Mechanical Engineering, Kielce University of Technology, 25-314 Kielce, Poland
Department of Biomaterials and Medical Devices Engineering, Faculty of Biomedical Engineering, Silesian University of Technology, 41-800 Zabrze, Poland
Materials Research Laboratory, Faculty of Mechanical Engineering, Silesian University of Technology, 44-100 Gliwice, Poland
Łukasiewicz Research Network – Poznań Institute of Technology, 61-755 Poznań, Poland
Funding
European Commission · Narodowe Centrum Nauki
References (82)
Show source-provided references
1. 10.12998/wjcc.v3.i1.5210.12998/wjcc.v3.i1.52 ↗
2. Nag S. · 2012 · 23 · 6
3. 10.1504/IJMMP.2018.09778410.1504/IJMMP.2018.097784 ↗
4. 10.1016/j.biomaterials.2005.10.00310.1016/j.biomaterials.2005.10.003 ↗
5. 10.3390/met1203037510.3390/met12030375 ↗
6. Dobrzański L. A. · 2021
7. Gupta M. · 2011 · 11310.1002/9780470905098.ch5 ↗
8. 10.1016/j.matdes.2021.11032710.1016/j.matdes.2021.110327 ↗
9. 10.1016/j.actbio.2012.03.00910.1016/j.actbio.2012.03.009 ↗
10. 10.1016/j.jnoncrysol.2018.02.02810.1016/j.jnoncrysol.2018.02.028 ↗
11. 10.1021/acsami.4c0471410.1021/acsami.4c04714 ↗
12. 10.1016/j.biomaterials.2004.09.04910.1016/j.biomaterials.2004.09.049 ↗
13. 10.1016/j.jma.2017.08.00310.1016/j.jma.2017.08.003 ↗
14. 10.1016/j.biomaterials.2007.12.02110.1016/j.biomaterials.2007.12.021 ↗
15. 10.1016/j.mseb.2011.04.00610.1016/j.mseb.2011.04.006 ↗
16. 10.1016/j.actbio.2009.06.02810.1016/j.actbio.2009.06.028 ↗
17. 10.1016/j.actbio.2012.02.01810.1016/j.actbio.2012.02.018 ↗
18. 10.1016/j.surfin.2018.11.01110.1016/j.surfin.2018.11.011 ↗
19. 10.1016/j.msec.2008.08.02410.1016/j.msec.2008.08.024 ↗
20. 10.3390/ma501013510.3390/ma5010135 ↗
21. 10.1016/j.matlet.2008.06.02810.1016/j.matlet.2008.06.028 ↗
22. 10.1016/j.corsci.2009.09.03310.1016/j.corsci.2009.09.033 ↗
23. 10.1007/s11661-019-05318-610.1007/s11661-019-05318-6 ↗
24. 10.1016/j.scriptamat.2009.06.00310.1016/j.scriptamat.2009.06.003 ↗
25. 10.1080/09506608.2017.142143910.1080/09506608.2017.1421439 ↗
26. 10.1007/s10853-020-04742-z10.1007/s10853-020-04742-z ↗
27. 10.1016/j.actbio.2007.09.01210.1016/j.actbio.2007.09.012 ↗
28. 10.1016/S1452-3981(23)05052-610.1016/S1452-3981(23)05052-6 ↗
29. Gierzyńska-Dolna M. · Plastic Form. Met. · 2012 · 23 · 181
30. 10.5604/01.3001.0016.160310.5604/01.3001.0016.1603 ↗
31. 10.3390/ma805274910.3390/ma8052749 ↗
32. Singh H. · Int. J. Emerg. Technol. Innov. Res. · 2019 · 6 · 2140
33. Zdero R. · 2017 · 29910.1016/B978-0-12-803802-4.00019-6 ↗
34. Fischer A. · 2018 · 2910.1007/978-3-319-99897-8_2 ↗
35. 10.3390/instruments303003510.3390/instruments3030035 ↗
36. 10.1016/j.pmatsci.2008.06.00410.1016/j.pmatsci.2008.06.004 ↗
37. Łaskawiec J. · 2002
38. Marciniak J. · 2008
39. 10.1016/j.wear.2021.20383610.1016/j.wear.2021.203836 ↗
40. Affatato S. · 2013 · 310.1533/9780857096128.1.3 ↗
41. 10.1016/j.mseb.2011.08.00810.1016/j.mseb.2011.08.008 ↗
42. 10.1016/S0079-6425(99)00010-910.1016/S0079-6425(99)00010-9 ↗
43. 10.1080/21663831.2022.207524310.1080/21663831.2022.2075243 ↗
44. 10.1007/s12540-021-00998-510.1007/s12540-021-00998-5 ↗
45. 10.1007/s40195-016-0451-910.1007/s40195-016-0451-9 ↗
46. 10.1016/j.jma.2020.12.01710.1016/j.jma.2020.12.017 ↗
47. 10.1016/j.hansur.2022.01.01210.1016/j.hansur.2022.01.012 ↗
48. 10.3390/jpm1302035710.3390/jpm13020357 ↗
49. 10.1016/j.jmrt.2022.06.17810.1016/j.jmrt.2022.06.178 ↗
50. 10.24425/12241310.24425/122413 ↗
51. ISO 6506-1: Metallic Materials─Brinell Hardness Test─Part 1: Test Method, 2014.
52. PN-EN ISO 6507-3 Metallic Materials─Vickers Hardness Test─Part 3: Calibration of Reference Blocks; British standard: Warsaw, 2018.
53. ANSI/AAMI. ISO 10993-5: Biological Evaluation of Medical Devices─Part 5. Tests for Cytotoxicity: In Vitro Methods; ANSI/AAMI: Arlington, VA, 1999.
54. 10.24425/bpasts.2023.14556410.24425/bpasts.2023.145564 ↗
55. 10.20964/11040289710.20964/110402897 ↗
56. 10.1016/j.jallcom.2014.04.05910.1016/j.jallcom.2014.04.059 ↗
57. 10.1016/j.rinp.2019.01.09510.1016/j.rinp.2019.01.095 ↗
58. 10.1007/s12666-015-0530-z10.1007/s12666-015-0530-z ↗
59. 10.1080/10426914.2023.219590910.1080/10426914.2023.2195909 ↗
60. 10.1179/175158309X1258638241837310.1179/175158309X12586382418373 ↗
61. 10.1115/1.405286710.1115/1.4052867 ↗
62. 10.5604/01.3001.0013.544010.5604/01.3001.0013.5440 ↗
63. 10.1016/j.triboint.2014.02.02410.1016/j.triboint.2014.02.024 ↗
64. 10.1016/j.wear.2022.20459210.1016/j.wear.2022.204592 ↗
65. 10.1016/j.jma.2018.08.00210.1016/j.jma.2018.08.002 ↗
66. Das, A. Spark Plasma Sintering of Magnesium Matrix, Bachelor’s Dissertation, Bangladesh University of Engineering and Technology, 2012. https://core.ac.uk/download/pdf/215223936.pdf.
67. 10.1016/j.wear.2013.02.01610.1016/j.wear.2013.02.016 ↗
68. 10.1016/j.mtcomm.2023.10735010.1016/j.mtcomm.2023.107350 ↗
69. Molnárová, O.; Málek, P.; Németh, G.; Kozlík, J.; Lukac, F.; Chraska, T.; Cinert, J. The Investigation of an Al7075 Alloy Prepared by Spark Plasma Sintering of Milled Powders. METAL 2016─25th Anniversary International Conference on Metallurgy and Materials, Conference Proceedings, 2016, 1200–1205. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010822212&partnerID=MN8TOARS.
70. 10.1016/j.matlet.2007.12.05210.1016/j.matlet.2007.12.052 ↗
71. 10.1016/j.jacomc.2024.10001110.1016/j.jacomc.2024.100011 ↗
72. 10.1016/j.msea.2021.14180910.1016/j.msea.2021.141809 ↗
73. 10.3390/bios1211095210.3390/bios12110952 ↗
74. 10.1039/C7NR00835J10.1039/C7NR00835J ↗
75. 10.3389/fimmu.2019.0279810.3389/fimmu.2019.02798 ↗
76. 10.1016/j.actbio.2019.10.01410.1016/j.actbio.2019.10.014 ↗
77. 10.1007/s11837-019-03371-510.1007/s11837-019-03371-5 ↗
78. 10.1016/j.msec.2017.11.02110.1016/j.msec.2017.11.021 ↗
79. 10.1016/j.msec.2011.07.01510.1016/j.msec.2011.07.015 ↗
80. 10.1016/j.actbio.2021.06.00410.1016/j.actbio.2021.06.004 ↗
81. 10.1080/17425247.2022.211006510.1080/17425247.2022.2110065 ↗
82. 10.1016/j.bioactmat.2022.12.01210.1016/j.bioactmat.2022.12.012 ↗