journal article·2024-04-28

Biomimicking TRPM8: A Conversely Temperature-Dependent Nonionic Retrorse Nanochannel for Ion Flow Control

Tao Yang, Zelin Yang, Weiwen Xin, Yuchen Feng, Xiangyu Kong, Yao Wang, Hao Li, Liping Wen, Guofu Zhou

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Abstract

Ion channels play a crucial role in the transmembrane transport and signal transmission of substances. In animals, transient receptor potential vanilloid 1 (TRPV1) and transient receptor potential melastatin 8 (TRPM8) serve as temperature-sensing units in sensory nerve endings. TRPV1 allows cells to sense heat, while TRPM8 enables them to detect cold, both serving to protect living organisms from harmful substances and environments. However, almost all studies on artificial nanochannels have mainly focused on TRPV1-like “forward nanochannels” thus far, which are incapable of “backward” responding to heat. So, we constructed an innovational TRPM8-inspired “retrorse nanochannel” through internal modification of poly(acrylamide- co -acrylonitrile) [P(AAm- co -AN)] with an upper critical solution temperature (UCST). Our results demonstrated that the internally modified nanochannels exhibited rapid, stable, and reversible heat-closing capability and converse temperature dependence within the typical temperature range of 25–40 °C. The biomimetic ion channel can effectively function as a facile, precise, and reversible thermal gate for controlling the transport of ions and substances. It also offers a promising microscopic technology for managing thermal effects on the substance, fluid, energy, and even signal delivery.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Ion Channels and Receptors · Nanopore and Nanochannel Transport Studies · Lipid Membrane Structure and Behavior

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangdong Provincial Key Laboratory of Optical Information Materials and Technology and Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, P. R. China

National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou 510006, P. R. China

Key Laboratory of Bio-inspired Materials and Interfacial Science Technical, Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China

School of Future Technology, Fujian Agriculture and Forestry University, Fuzhou 350002, P. R. China

Funding

Basic and Applied Basic Research Foundation of Guangdong Province · Guangzhou Municipal Science and Technology Project · National Natural Science Foundation of China · Higher Education Discipline Innovation Project · South China Normal University · Guangdong Provincial Key Laboratory of Optical Information Materials and Technology · MOE International Laboratory for Optical Information Technologies · Guangdong Science and Technology Project–International Cooperation

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