DataVXACS Applied Materials & InterfacesPaper
journal article·2022-06-22Open access

Drug-Eluting Rubber Bands for Tissue Ligation

Ron Feiner, Eleanor Johns, Merav Antman-Passig, Takeshi Irie, Naxhije Berisha, Hadas Oved, Doha Khan, Lukasz Witek, Richard M. White, Daniel A. Heller

ACS Applied Materials & Interfaces· Volume 14· Issue 24
Publisher pageOpen full text
Source abstract

Abstract

Rubber band ligation is a commonly used method for the removal of tissue abnormalities. Most often, rubber band ligation is performed to remove internal hemorrhoids unresponsive to first line treatments to avoid surgery. While the procedure is considered safe, patients experience mild to significant pain and discomfort until the tissue sloughs off. As patients often require multiple bandings and sessions, reducing these side effects can have a considerable effect on patient adherence and quality of life. To reduce pain and discomfort, we developed drug-eluting rubber bands for ligation procedures. We investigated the potential for a band to elute anesthetics and drug combinations to durably manage pain for a period of up to 5 days while exhibiting similar mechanical properties to conventional rubber bands. We show that the rubber bands retain their mechanical properties despite significant drug loading. Lidocaine, released from the bands, successfully altered the calcium dynamics of cardiomyocytes in vitro and modulated heart rate in zebrafish embryos, while the bands exhibited lower cytotoxicity than conventional bands. Ex vivo studies demonstrated substantial local drug release in enteric tissues. These latex-free bands exhibited sufficient mechanical and drug-eluting properties to serve both ligation and local analgesic functions, potentially enabling pain reduction for multiple indications.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Surgical Sutures and Adhesives · Veterinary Pharmacology and Anesthesia · Anesthesia and Pain Management

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States

Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States

Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States

Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States

Department of Nanotechnology, Advanced Science Research Center (ASRC) at the Graduate Center of the City University of New York, New York, New York 10031, United States

Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel

Division of Biomaterials, Department of Molecular Pathobiology, NYU College of Dentistry, New York, New York 10010, United States

Department of Biomedical Engineering, NYU Tandon School of Engineering, Brooklyn, New York 11201, United States

Weill Cornell Medical College, New York, New York 10065, United States

Funding

National Cancer Institute · National Institute of Arthritis and Musculoskeletal and Skin Diseases · Division of Chemical, Bioengineering, Environmental, and Transport Systems · Commonwealth Foundation for Cancer Research Foundation · Thompson Family Foundation · Experimental Therapeutics Center, Memorial Sloan-Kettering Cancer Center

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