DataVXACS Applied Materials & InterfacesPaper
journal article·2022-10-19

Intracellular Delivery of Micron-Sized Magnetic Particles through a Virus Infection Pathway

Xiayi Feng, Ding Gao, Yipeng Jing, Junchao Qian, Zongqiang Cui, Juan Zhou, Xian-En Zhang, Dong Men

ACS Applied Materials & Interfaces· Volume 14· Issue 41
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Source abstract

Abstract

Micron-sized magnetic particles (M-MPs) have low toxicity, strong magnetic signals, and long-term retention capability, which are significant advantages for their application in biomedical imaging. Unfortunately, M-MPs are only internalized by few cell types, such as macrophages and phagocytes, and because of this lack of active intracellular delivery, their applications are restricted. The emergence of self-assembled virus-like particles (VLPs) offers a viable approach to drive M-MPs into cells, although the specific mechanism has not been revealed. In this study, we investigated in detail the intracellular pathway of M-MPs mediated by VLPs using a fluorescence co-localization method. The results indicated that the intracellular movement of M-MPs was consistent with the virus infection pathway, specifically caveolae-dependent endocytosis, transportation through microtubules, and accumulation in the endoplasmic reticulum. This study provides experimental support for the active transport of M-MPs into other cell types, thereby further extending their applications.
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Research context

OpenAlex topics: Characterization and Applications of Magnetic Nanoparticles · Microfluidic and Bio-sensing Technologies · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, PR China

University of Chinese Academy of Sciences, Beijing 100049, PR China

Nursing and Health College, Henan University, Kaifeng 475004, PR China

The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, PR China

Hefei Cancer Hospital, Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, PR China

Faculty of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, PR China

National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, PR China

Funding

National Natural Science Foundation of China · Chinese Academy of Sciences · Knowledge Innovation Program of Wuhan-Shuguang Project

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