journal article·2023-02-08

In Situ Interfacial Super-Assembly of Nanobiohybrids through Plant for Food-Grade Oral Medicine

Wenlong Fu, Lei Xie, Jicheng Yu, Yanjun He, Jie Zeng, Jian Liu, Kang Liang, Pu Chen, Lei Jiang, Zhen Gu, Biao Kong

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Abstract

Developing a next-generation oral drug delivery system with enhanced efficacy and limited side effects is highly desired for refractory diseases treatment such as colitis. The bioinspired assembly of drugs within food-grade plants highlights its potential value of this unique hybrid material. Herein, we report the preparation of drug-encapsulated vegetable nanobiohybrid superassembled frameworks as an oral food-grade drug delivery system (SAF-FGDD). The in situ superassembly of SAF-FGDD driven by natural transpiration from living plants is carried out through a sustainable and low-carbon manner, allowing for the assembly of distinct precursors inside edible living plants. As an example, mesalazine, an anti-inflammatory drug, is encapsulated in the frameworks for colitis treatment. The cell activity and feeding experiments of zebrafish and mice demonstrate the excellent efficacy of this SAF-FGDD. Compared with those of the control groups, the disease activity index scores and histological scores of the SAF-FGDD group were significantly decreased by 80% and 98%, respectively. The improved performance is attributed to the biocompatibility and protective effect of SAF-FGDD, allowing for abundant mesalazine to be released and act at the site of the intestine during the process of food digestion. In combination with mature soilless cultivation technology, plant-based organisms with natural structure-forming abilities possess broad commercial prospects in large-scale production of various food-grade functional materials.
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Research context

OpenAlex topics: Advanced Drug Delivery Systems

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Affiliations

Department of Chemistry, Shanghai Key Lab of Molecular Catalysis and Innovative Materials, Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai 200438, P. R. China

School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, P. R. China

Zhejiang Provincial Key Laboratory of Advanced Drug Delivery Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China

State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China

School of Chemical Engineering, Graduate School of Biomedical Engineering, and Australian Centre for NanoMedicine, University of New South Wales, Sydney NSW 2052, Australia

Department of Chemical Engineering, University of Waterloo, Ontario N2L 3G1, Canada

CAS Key Laboratory of Bio-Inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China

Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, P. R. China

Zhejiang Laboratory of Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou 311121, P. R. China

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China

Yiwu Research Institute of Fudan University, Yiwu, Zhejiang 322000, P. R. China

Funding

Fudan University · Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China

References (45)

Show source-provided references
1. 10.1016/j.disamonth.2019.02.00410.1016/j.disamonth.2019.02.004 ↗
2. 10.14309/ajg.000000000000018310.14309/ajg.0000000000000183 ↗
3. 10.1038/s41572-020-0205-x10.1038/s41572-020-0205-x ↗
4. 10.7573/dic.21257210.7573/dic.212572 ↗
5. 10.1517/14740338.6.2.9910.1517/14740338.6.2.99 ↗
6. 10.3748/wjg.v17.i27.320410.3748/wjg.v17.i27.3204 ↗
7. 10.1111/apt.1468810.1111/apt.14688 ↗
8. 10.1038/s41565-019-0485-z10.1038/s41565-019-0485-z ↗
9. 10.1021/acs.accounts.9b0028310.1021/acs.accounts.9b00283 ↗
10. 10.1021/acs.chemmater.1c0062910.1021/acs.chemmater.1c00629 ↗
11. 10.1038/srep1903210.1038/srep19032 ↗
12. 10.3390/nu408109510.3390/nu4081095 ↗
13. 10.1038/s43016-021-00398-310.1038/s43016-021-00398-3 ↗
14. 10.3390/nu1107149810.3390/nu11071498 ↗
15. 10.5152/tjg.2015.010610.5152/tjg.2015.0106 ↗
16. 10.1097/MEG.0b013e3283352d0510.1097/MEG.0b013e3283352d05 ↗
17. 10.1097/MD.000000000000907010.1097/MD.0000000000009070 ↗
18. 10.1016/j.clnu.2016.10.00910.1016/j.clnu.2016.10.009 ↗
19. 10.1038/s41596-020-00421-010.1038/s41596-020-00421-0 ↗
20. 10.1038/s43016-021-00421-710.1038/s43016-021-00421-7 ↗
21. 10.1080/10408398.2019.163451710.1080/10408398.2019.1634517 ↗
22. 10.1111/jfbc.1353610.1111/jfbc.13536 ↗
23. 10.3390/cells1004075610.3390/cells10040756 ↗
24. 10.1016/j.foodchem.2021.13061010.1016/j.foodchem.2021.130610 ↗
25. 10.1097/MEG.000000000000033010.1097/MEG.0000000000000330 ↗
26. 10.1021/acs.accounts.9b0007910.1021/acs.accounts.9b00079 ↗
27. 10.1038/s41565-021-00910-710.1038/s41565-021-00910-7 ↗
28. 10.1021/jacs.7b1111410.1021/jacs.7b11114 ↗
29. 10.1038/s43016-021-00269-x10.1038/s43016-021-00269-x ↗
30. 10.1126/science.aay486610.1126/science.aay4866 ↗
31. 10.1002/anie.20200938710.1002/anie.202009387 ↗
32. 10.1021/jacs.1c0482110.1021/jacs.1c04821 ↗
33. 10.1002/smll.20130194010.1002/smll.201301940 ↗
34. 10.1038/s41467-019-11898-z10.1038/s41467-019-11898-z ↗
35. 10.1038/nchem.240510.1038/nchem.2405 ↗
36. 10.1021/jacs.1c0054710.1021/jacs.1c00547 ↗
37. 10.1002/anie.20211073110.1002/anie.202110731 ↗
38. 10.1021/acs.analchem.0c0497610.1021/acs.analchem.0c04976 ↗
39. 10.1021/jacs.1c1039110.1021/jacs.1c10391 ↗
40. 10.1002/anie.20220024010.1002/anie.202200240 ↗
41. 10.1126/sciadv.aaz033010.1126/sciadv.aaz0330 ↗
42. 10.1038/s41893-020-0567-910.1038/s41893-020-0567-9 ↗
43. 10.1016/j.scienta.2021.11073610.1016/j.scienta.2021.110736 ↗
44. 10.1021/cr200101d10.1021/cr200101d ↗
45. 10.1021/acsami.7b0938710.1021/acsami.7b09387 ↗