journal article·2023-05-31

In Vivo Formation and Tracking of π-Peptide Nanostructures

Jessie P. Dibble, Scott R. Deboer, Mahlet Mersha, Thomas J. Robinson, Ryan J. Felling, Steven R. Zeiler, John D. Tovar

ACS Applied Materials & Interfaces· Volume 15· Issue 21
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Abstract

The photophysics associated with the self-assembly of π-peptide molecules into 1-D nanostructures has been well-established, thus revealing the creation of nanoscale electronic conduits in aqueous media. Such materials have therapeutic potential in many biomedical applications. In this work, we report the in vivo deployment of these π-peptide nanostructures in brain tissue using photothrombotic stroke as a model application. A test peptide was used for brain injections, and the nanostructures formed were visualized with electron microscopy. A new peptide bearing a low-energy fluorescence dye was prepared to facilitate direct visualization of π-peptide localization in the brain cavity by way of fluorescence microscopy. This work demonstrates feasibility for in vivo application of π-peptide nanostructures toward pressing biomedical challenges.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Supramolecular Self-Assembly in Materials · RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, United States

Medstar Franklin Square Medical Center, 9000 Franklin Square Drive, Baltimore, Maryland 21237, United States

Department of Neurology, Johns Hopkins School of Medicine, 600 N. Wolfe Street, Baltimore, Maryland 21287, United States

Department of Pediatrics, Johns Hopkins School of Medicine, 1800 Orleans Street, Baltimore, Maryland 21287, United States

Department of Materials Science and Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, United States

Funding

Johns Hopkins University

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