DataVXACS Applied Materials & InterfacesPaper
journal article·2015-08-12

Supramolecular Peptide/Surface Assembly for Monitoring Proteinase Activity and Cancer Diagnosis

Claire Soum, Sandra Rubio-Albenque, Suzanne Fery-Forgues, Gérard Déléris, Mohamed-Anis Alouini, Thomas Berthelot

ACS Applied Materials & Interfaces· Volume 7· Issue 31
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Source abstract

Abstract

Matrix metalloproteinases (MMP) are a family of proteolytic enzymes, the expression of which in a key step of tumor progression has recently been better defined. The overexpression of one or more MMPs is thus common among malignant tumors. It may characterize tumor progression and help predict its response to chemotherapy. Consequently, the development of a device for measuring MMP activities is an important challenge for diagnosis and prognosis. In this study, we describe an innovative supramolecular peptide/surface assembly for screening MMP activities. This sensor was used to discriminate various MMP activities and to distinguish between invasive and noninvasive cancerous cell suspensions. Our results confirm the proof-of-concept of a powerful tool for the determination of the tumor aggressiveness and a technical building block for future development of MMP lab-on-chip devices.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Protease and Inhibitor Mechanisms · Advanced biosensing and bioanalysis techniques · Peptidase Inhibition and Analysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Pharmacochimie, FRE3396 CNRS, University of Bordeaux, 146 rue Léo Saignat, F-33076 Bordeaux Cedex, France

Laboratory of Innovation in Surface Chemistry and Nanosciences, NIMBE UMR CNRS 3685, CEA Saclay, DSM/IRAMIS/NIMBE/LICSEN, F-91191, Gif-sur-Yvette Cedex, France

Institut des Technologies Avancées en sciences du Vivant (ITAV), CNRS UMS 3039, Centre Pierre Potier, Oncopôle, 1 place Pierre Potier, BP 50624, F-31106 Toulouse Cedex 1, France

LSPCMIB, UMR-CNRS 5068, Université Paul Sabatier-Toulouse III, 118, route de Narbonne, F-31062 Toulouse Cedex 9, France

Funding

R?gion Aquitaine · Commissariat ? l'?nergie Atomique et aux ?nergies Alternatives · Centre National de la Recherche Scientifique

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