DataVXACS Applied Materials & InterfacesPaper
journal article·2017-03-15

Controlled PEGylation Crowdedness for Polymeric Micelles To Pursue Ligand-Specified Privileges as Nucleic Acid Delivery Vehicles

Xiyi Chen, Haifeng Gu, Jinjun Yang, Sudong Wu, Jun Liu, Xi Yang, Qixian Chen

ACS Applied Materials & Interfaces· Volume 9· Issue 10
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Source abstract

Abstract

A facile poly(ethylene glycol) (PEG) detachment scheme was utilized to control the PEGylation degree of the polymeric micelles. The performance of cyclic Arg-Gly-Asp (cRGD) as a targeted moiety was studied on a class of polymeric micelles with various PEGylation degrees, revealing that the specific cRGD-mediated cell affinity, thus the cellular uptake and implicated privileges including the ligand-specified favorable intracellular trafficking and consequent favorable biofunctions, was prominent for the polymeric micelles with high PEGylation degree. These results endow important information and implications for the design and development of targeted nanomedicine, particularly the delivery of vulnerable biological compounds.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: RNA Interference and Gene Delivery · Nanoparticle-Based Drug Delivery · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Public Health, Dalian Medical University, No. 9 West Section, Lvshun South Road, Dalian 116044, China

College of Science, Dalian Ocean University, No. 52 Heishijiao Street, Dalian 116023, China

School of Environmental Science and Safety Engineering, Tianjin University of Technology, Xiqing District, Tianjing 300384, China

Ningbo Institute of Materials Technology and Engineering, China Academy of Sciences, Ningbo 315201, China

Ningbo Hygeia Medical Technology Company, Ltd., No. 1177 Lingyun Road, High-Tech Zone, Ningbo 315040, China

Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

Funding

Natural Science Foundation of Tianjin City · National Natural Science Foundation of China

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