DataVXACS Applied Materials & InterfacesPaper
journal article·2026-04-29

Temporally Programmed and Laser-Triggered Immunomodulatory Hydrogel Enables Synergistic Wound Healing and Prevention of Postoperative Tumor Recurrence

Shuo Shan, Shunli Fu, Zheng Ma, Lianghong Lü, Weihua Wang, Limin Li, Qian Yu, Haizhen Wang, Chenyang Zhao, Alvaro W. Mombrú, Dominique Mombrú, Mariano Romero, Helena Pardo, Chao Gao, He Ren, Tiemin Zhang

ACS Applied Materials & Interfaces· Volume 18· Issue 16
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Source abstract

Abstract

Surgery remains the predominant therapeutic option for patients with colorectal cancer. However, residual microscopic lesions and the immunosuppressive microenvironment considerably elevate the risk of postoperative tumor recurrence. Additionally, intestinal fistulas are the most common complication of surgery and severely impair the quality of life for patients. Current postoperative adjuvant therapies are limited by their systemic toxicity, inadequate immunomodulatory potential, and poor tumor targeting capacity, resulting in limited therapeutic efficacy. To address these challenges, a multifunctional hydrogel system that combined temporally programmed and laser-triggered release of specific drugs for integrated wound repair, precision tumor ablation, and the prevention of postoperative tumor recurrence was developed herein. A Pluronic F127-chitosan hydrogel scaffold was synthesized and coloaded with curcumin and thermosensitive liposomes (PR-Lip) encapsulating R848-loaded mesoporous polydopamine (MPDA). Following in situ implantation at the surgical site, the temperature responsiveness and adhesive properties of the hydrogel prevent the formation of intestinal fistulas. The preferential release of curcumin promotes wound healing and inhibits the recruitment of immunosuppressive cells, thereby alleviating local immunosuppression in an early postoperative stage. Subsequent laser irradiation triggers the release of MPDA and R848 from PR-Lip, enabling localized ablation of residual tumors, initiating potent T-cell-mediated immune responses, and reversing the immunosuppressive tumor microenvironment. This study presents a novel and comprehensive postoperative treatment strategy with the potential capacity to achieve 40% tumor remission rates, thereby advancing the development of intelligent and functionally integrated adjuvant therapies for the postoperative treatment of solid tumors.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersBiomaterials

OpenAlex topics: Wound Healing and Treatments · Nanoplatforms for cancer theranostics · Hydrogels: synthesis, properties, applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Gastrointestinal Oncology Surgery

The Second Affiliated Hospital of Hainan Medical University

Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases

The Affiliated Hospital of Qingdao University, Qingdao University

China Uruguay Bio-nano Pharmaceutical Joint Laboratory

Laboratory for Future Industry in Cytotherapy Immunity and Gene Editing at Higher Education Institutions in Shandong Province

Department of Gastrointestinal Surgery

The Affiliated Hospital of Qingdao University

Institute of Biomedical Engineering, College of Life Sciences

Qingdao University

Centro NanoMat & Área Física, Departamento de Experimentación y Teoría de la Estructura de la Materia y sus Aplicaciones -DETEMA, Facultad de Química

Universidad de la República

Gastrointestinal Cancer Institute (Pancreatic Disease Institute)

Gastrointestinal Surgery

Heyou Hospital

Funding

Natural Science Foundation of Hainan Province · National Science Fund for Distinguished Young Scholars · Natural Science Foundation of Shandong Province · Medicine Plus' Joint Research Program of Qingdao University · Hainan Provincial Clinical Medical Center Program · Qingdao Natural Science Foundation · Youth Science Foundation of the Affiliated Hospital of Qingdao University · Key Program of National Natural Science Foundation of China · Innovative Research Projects for Postgraduate Students in Regular Higher Education Institutions of Hainan Province · "Intergovernmental International Cooperation on Science and Technology Innovation" National Key R&D Program of China · Taishan Scholars Program of Shandong Province

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