DataVXACS Applied Materials & InterfacesPaper
journal article·2026-04-22

Heat and Heal: Microwave-Responsive Gelling Hydrogel Nanocomposites for Postablation Extracellular Matrix Normalization and Chemotherapy Sensitization

Yuting Cao, Xinyu Zhong, Qing Li, Pan Li, Qinghai Peng, Long Wang, Chengcheng Niu

ACS Applied Materials & Interfaces· Volume 18· Issue 15
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Source abstract

Abstract

-rich core and a tranilast-loaded shell, into alginate solution. Under microwave irradiation, the polar salt core generated rapid heating, ruptured, and released calcium ions, which cross-linked alginate to form a stable hydrogel in situ. By integrating microwave sensitization with postablation microenvironment regulation, this strategy simultaneously resolves insufficient heating and aberrant ECM remodeling, enabling improved chemotherapeutic efficacy. This simple and biocompatible platform provides a rational approach for improving local tumor MWA and reducing postablation recurrence.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterialsBiomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Hepatocellular Carcinoma Treatment and Prognosis · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Ultrasound Diagnosis, The Second Xiangya Hospital

Central South University

Research Center of Ultrasonography, The Second Xiangya Hospital

Clinical Research Center for Ultrasound Diagnosis and Treatment in Hunan Province

Department of Ultrasound, Third Xiangya Hospital

Department of Ultrasound

Affiliated Hospital of Youjiang Medical University for Nationalities

Department of Ultrasound, Chongqing Key Laboratory of Ultrasound Molecular Imaging

The First Affiliated Hospital of Chongqing Medical University

Department of Orthopedics, Xiangya Hospital

Funding

Natural Science Foundation of Hunan Province · Natural Science Foundation of Chongqing Municipality · China Postdoctoral Science Foundation · National Natural Science Foundation of China

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