Bletilla striata Polysaccharide-Functionalized Selenium Nanoparticles: A Treatment Strategy for Gastric Ulcers Based on Nano Biocomposites
Source abstract
Abstract
Gastric ulcer (GU) is a common gastrointestinal disease, and its treatment still faces challenges such as high recurrence rate and side effects. Selenium nanoparticles (Se NPs) have emerged as a promising candidate for the treatment of gastric ulcers due to their potent antioxidant and anti-inflammatory properties. However, the application of Se NPs is hindered by their poor stability and low bioavailability. Here, BSP-modified Se NPs (BSP-Se NPs) were synthesized using Bletilla striata polysaccharide (BSP) as a stabilizer. The results showed that BSP-Se NPs displayed good dispersion with a particle size of 77.24 ± 3.17 nm. BSP-Se NPs exhibited preferential accumulation and prolonged circulation time in gastric tissues as well as enhanced cellular uptake, thereby improving their bioavailability. The results of in vivo animal experiments demonstrated that BSP-Se NPs significantly improved the ulcer index (UI) and increased ulcer inhibition rate in GU mice. Additionally, BSP-Se NPs significantly inhibited the expression of inflammatory factors, improved the levels of oxidative stress markers, ameliorated the pathological damage of gastric tissues, and restored the gastric mucosal barrier, thus effectively treating ethanol-induced GU. Overall, the therapeutic effect of BSP-Se NPs on gastric ulcers highlights their potential as a promising treatment strategy for this prevalent gastrointestinal condition.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Traditional Chinese Medicine Analysis · Berberine and alkaloids research · Wound Healing and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Food and Health
Zhejiang A&F University
Jilin Province Changbai Mountain Edible Plant Resources Development Engineering Centre, Antibody Development Jilin Province University Enterprise Joint Technology Innovation Laboratories
Tonghua Normal University
Spice and Beverage Research Institute, Chinese Academy of Tropical Agricultural Sciences, National Center of Important Tropical Crops Engineering and Technology Research
Key Laboratory of Processing Suitability and Quality Control of the Special Tropical Crops of Hainan Province
National Key Laboratory for Tropical Crop Breeding
Sanya Research Institute, Chinese Academy of Tropical Agriculture Sciences
Funding
Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences · Research Development Foundation of Zhejiang A&F University · National Natural Science Foundation of China (NSFC)
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